Gene Review:
J3R - chemokine binding protein
Monkeypox virus Zaire-96-I-16
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Disease relevance of J3R
- J3R, the 39-kDa subunit of vaccinia virus poly(A) polymerase, is a multifunctional protein that catalyzes (nucleoside-2'-O-)-methyltransferase activity, serves as a poly(A) polymerase stimulatory factor, and acts as a postreplicative positive transcription elongation factor [1].
High impact information on J3R
- H4L binds to the C-terminal region of J3R between amino acids 169 and 333 [1].
- The NPH I binding site was located on J3R between amino acids 169 and 249, and J3R was shown to bind to NPH I between amino acids 457 and 524 [1].
- Analysis of transcription activity demonstrated that J3R is not required for early mRNA synthesis and is not an essential factor in early gene transcription termination or transcript release in vitro [1].
Other interactions of J3R
- Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase [1].
References
- Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase. Mohamed, M.R., Latner, D.R., Condit, R.C., Niles, E.G. Virology (2001) [Pubmed]
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