Gene Review:
SP_1999 - catabolite control protein A
Streptococcus pneumoniae TIGR4
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Disease relevance of SP_1999
- We characterized the role of catabolite control protein A (ccpA) in the physiology and virulence of Streptococcus pneumoniae [1].
- CcpA is the major transcriptional regulator in CCR in several gram-positive bacteria [1].
High impact information on SP_1999
- Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae [1].
- Comparison of the cell wall fraction of the ccpA and wild-type strains shows that CcpA regulates many proteins in this compartment that are involved in central and intermediary metabolism, a subset of which are required for survival and multiplication in vivo [1].
- Our results demonstrate that CcpA, though not a global regulator of CCR in S. pneumoniae, is required for colonization of the nasopharynx and survival and multiplication in the lung [1].
References
- Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae. Iyer, R., Baliga, N.S., Camilli, A. J. Bacteriol. (2005) [Pubmed]
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