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Gene Review

SP_1999  -  catabolite control protein A

Streptococcus pneumoniae TIGR4

 
 
 
 
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Disease relevance of SP_1999

 

High impact information on SP_1999

  • Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae [1].
  • Comparison of the cell wall fraction of the ccpA and wild-type strains shows that CcpA regulates many proteins in this compartment that are involved in central and intermediary metabolism, a subset of which are required for survival and multiplication in vivo [1].
  • Our results demonstrate that CcpA, though not a global regulator of CCR in S. pneumoniae, is required for colonization of the nasopharynx and survival and multiplication in the lung [1].

References

 
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