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Gene Review:

m010L - MGF

Myxoma virus

Strayer, D.S. et al., Opgenorth, A. et al., McCabe, V.J. et al., McCabe, V.J. et al., Opgenorth, A. et al.

McCabe, Spibey,

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Disease relevance of m010L

Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor [1].
Transforming growth factor alpha, Shope fibroma growth factor, and vaccinia growth factor can replace myxoma growth factor in the induction of myxomatosis in rabbits [2].
The FCV capsid protein genes were inserted into the myxoma growth factor gene (MGF) locus, and the serine protease inhibitor (SERP 2) gene locus [3].
The FCV capsid genes were recombined into the myxoma growth factor (MGF) locus of the myxoma genome and expressed from synthetic poxvirus promoters [4].

High impact information on m010L

The family of epidermal growth factor-like growth factors includes a group of poxviral growth factors: Shope growth factor (SGF), myxoma growth factor MGF), and vaccinia growth factor [5].

References

Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor. Opgenorth, A., Graham, K., Nation, N., Strayer, D., McFadden, G. J. Virol. (1992) [Pubmed]
Transforming growth factor alpha, Shope fibroma growth factor, and vaccinia growth factor can replace myxoma growth factor in the induction of myxomatosis in rabbits. Opgenorth, A., Nation, N., Graham, K., McFadden, G. Virology (1993) [Pubmed]
Potential for broad-spectrum protection against feline calicivirus using an attenuated myxoma virus expressing a chimeric FCV capsid protein. McCabe, V.J., Spibey, N. Vaccine (2005) [Pubmed]
Vaccination of cats with an attenuated recombinant myxoma virus expressing feline calicivirus capsid protein. McCabe, V.J., Tarpey, I., Spibey, N. Vaccine (2002) [Pubmed]
Epidermal growth factor-like growth factors. I. Breast malignancies and other epithelial proliferations in transgenic mice. Strayer, D.S., Yang, S., Schwartz, M.S. Lab. Invest. (1993) [Pubmed]

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