Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

cinA - competence damage-inducible protein A

Streptococcus pneumoniae R6

Peterson, S. et al., Narumi, I. et al., Martin, B. et al., Mortier-Barrière, I. et al.

Narumi, Satoh, Kikuchi, Funayama, Kitayama, Yanagisawa, Watanabe, Yamamoto,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cinA

Predicted amino acid sequences of orf105a and orf105b showed substantial similarity to the competence-damage inducible protein (cinA gene product) from Streptococcus pneumoniae and the 2'-5' RNA ligase from Escherichia coli, respectively [1].

High impact information on cinA

A 5.7 kb recA-specific transcript that contained at least two additional genes, cinA and dinF, was identified [2].
The major (about 4.3 kb) transcript detected from non-competent cells did not include cinA, the first gene in the operon, suggesting that this gene could be specifically required at some stage in the transformation process [3].
Overlapping expression patterns for the genes cinA and comD (G. Alloing, B. Martin, C. Granadel, and J. P. Claverys, Mol. Microbiol. 29:75-83, 1998) suggest that at least two distinct regulatory mechanisms may underlie the competence cycle [4].

References

Molecular analysis of the Deinococcus radiodurans recA locus and identification of a mutation site in a DNA repair-deficient mutant, rec30. Narumi, I., Satoh, K., Kikuchi, M., Funayama, T., Kitayama, S., Yanagisawa, T., Watanabe, H., Yamamoto, K. Mutat. Res. (1999) [Pubmed]
Competence-specific induction of recA is required for full recombination proficiency during transformation in Streptococcus pneumoniae. Mortier-Barrière, I., de Saizieu, A., Claverys, J.P., Martin, B. Mol. Microbiol. (1998) [Pubmed]
The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls lysogenic induction. Martin, B., García, P., Castanié, M.P., Claverys, J.P. Mol. Microbiol. (1995) [Pubmed]
Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays. Peterson, S., Cline, R.T., Tettelin, H., Sharov, V., Morrison, D.A. J. Bacteriol. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.