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Gene Review

HHV8gp01  -  ORF K1

Human herpesvirus 8 type M

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Disease relevance of HHV8gp01

 

High impact information on HHV8gp01

  • 35, 0.85, and 0.96 revealed typical ORF-K1-linked subtype patterns, except that between 20 and 30% of the genomes analyzed proved to be either intertypic or intratypic mosaics [4].
  • The concept that HHV8 genomes fall into several distinct subgroups has been confirmed and refined by PCR DNA sequence analysis of the ORF-K1 gene encoding a highly variable glycoprotein related to the immunoglobulin receptor family that maps at the extreme left-hand end of the HHV-8 genome [1].
  • In addition, two alternative highly diverged forms of the complex spliced ORF-K15 gene (P or M) map at the extreme RHS of the genome and are essentially unlinked to the ORF-K1 genotypes [5].
  • Furthermore, the ORF K1 sequences were predominantly unique, assignable to genotypes A1, A4, and C3 [6].
  • The ORF-K1 subtype A5 was identified in samples from three patients with a B3/C2 type polymorphism in the ORF 26 gene [3].
 

Biological context of HHV8gp01

  • Patterns of intra- and extra-familial transmission inferred from ORF K1 sequencing data were corroborated mainly using ORF 73 IRD RFLP analysis [7].
  • Amino acid sequences of the ORF-K1 gene were used to construct a neighbor-joining phylogenetic tree [8].
 

Associations of HHV8gp01 with chemical compounds

  • Analysis of classic KS genomes from Israel has revealed that the ORF-K1 clade referred to as A1' predominates in Ashkenazi Jewish immigrants from Russia, whereas C2 and C6 variants predominate in North African Sephardi Jews [9].
  • Phylogenetic analysis revealed identical DNA sequence to ORF K1, and a close relation to its C1 variant [10].
 

Analytical, diagnostic and therapeutic context of HHV8gp01

References

  1. High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations. Zong, J.C., Ciufo, D.M., Alcendor, D.J., Wan, X., Nicholas, J., Browning, P.J., Rady, P.L., Tyring, S.K., Orenstein, J.M., Rabkin, C.S., Su, I.J., Powell, K.F., Croxson, M., Foreman, K.E., Nickoloff, B.J., Alkan, S., Hayward, G.S. J. Virol. (1999) [Pubmed]
  2. Effects of Kaposi's sarcoma-associated herpesvirus ORF K1 on differentiating endothelium in murine embryoid bodies and teratomas. Mebrahtu, S., Eriksson, U., Rauch, U., Warenholt, J., Bendsöe, N., Dictor, M. Exp. Cell Res. (2004) [Pubmed]
  3. HHV-8 subtypes in South Africa: identification of a case suggesting a novel B variant. Treurnicht, F.K., Engelbrecht, S., Taylor, M.B., Schneider, J.W., van Rensburg, E.J. J. Med. Virol. (2002) [Pubmed]
  4. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. Poole, L.J., Zong, J.C., Ciufo, D.M., Alcendor, D.J., Cannon, J.S., Ambinder, R., Orenstein, J.M., Reitz, M.S., Hayward, G.S. J. Virol. (1999) [Pubmed]
  5. KSHV strains: the origins and global spread of the virus. Hayward, G.S. Semin. Cancer Biol. (1999) [Pubmed]
  6. Human herpesvirus 8 genoprevalence in populations at disparate risks of Kaposi's sarcoma. Kumar, N., McLean, K., Inoue, N., Moles, D.R., Scully, C., Porter, S.R., Teo, C.G. J. Med. Virol. (2007) [Pubmed]
  7. Tracking familial transmission of Kaposi's sarcoma-associated herpesvirus using restriction fragment length polymorphism analysis of latent nuclear antigen. Cook, R.D., Hodgson, T.A., Molyneux, E.M., Borgstein, E., Porter, S.R., Teo, C.G. J. Virol. Methods (2002) [Pubmed]
  8. Ugandan Kaposi's sarcoma-associated herpesvirus phylogeny: evidence for cross-ethnic transmission of viral subtypes. Kajumbula, H., Wallace, R.G., Zong, J.C., Hokello, J., Sussman, N., Simms, S., Rockwell, R.F., Pozos, R., Hayward, G.S., Boto, W. Intervirology (2006) [Pubmed]
  9. Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism. Zong, J., Ciufo, D.M., Viscidi, R., Alagiozoglou, L., Tyring, S., Rady, P., Orenstein, J., Boto, W., Kalumbuja, H., Romano, N., Melbye, M., Kang, G.H., Boshoff, C., Hayward, G.S. J. Clin. Virol. (2002) [Pubmed]
  10. Molecular analysis of Kaposi's sarcoma occurring during haemodialysis. Metaxa-Mariatou, V., Chiras, T., Loli, A., Gazouli, M., Vallis, D., Nasioulas, G. Clin. Exp. Dermatol. (2004) [Pubmed]
  11. Genotypic distribution of human herpesvirus-8 strains circulating in HIV-positive patients with and without Kaposi's sarcoma in Hungary. Szalai, E., Takács, M., Otvös, R., Szlávik, J., Juhász, A., Berencsi, G. Arch. Virol. (2005) [Pubmed]
 
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