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Gene Review

Glp2r  -  glucagon-like peptide 2 receptor

Mus musculus

Synonyms: 9530092J08Rik, GLP-2, GLP-2 receptor, GLP-2-R, GLP-2R, ...
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Disease relevance of Glp2r

  • However, a significant effect of 1 microg/g(-1) per day(-1) GLP-2 was observed in Igf1(-/-) mice, but only in terms of small intestinal weight when normalized for body weight [1].
  • Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice [2].
  • The tumour promoting effect of native GLP-2 was less pronounced but the number of small sized polyps increased following long term treatment [2].
  • Our findings highlight the need for future investigations on the effects of GLP-2 in conditions needing long time treatment or with increased gastrointestinal cancer susceptibility [2].
  • We conclude that loss of DPIV activity does not increase resistance to experimental colitis and hypothesize that other DPIV family members may also be involved in the cleavage of GLP-2 [3].

Psychiatry related information on Glp2r


High impact information on Glp2r

  • RESULTS: GLP-2 increased IGF-1 messenger RNA expression and IGF-1 secretion in intestinal cultures and increased expression of IGF-1 messenger RNA in mouse small intestine in vivo [1].
  • GLP-2 is therefore a physiologic regulator of the dynamic adaptation of the gut mucosal epithelium in response to luminal nutrients [6].
  • CONCLUSIONS: These data show that endogenous GLP-2 regulates the intestinotropic response in re-fed mice through modulation of crypt-cell proliferation and villus apoptosis [6].
  • The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair [7].
  • Further analysis reveals that alphaTC-DeltaPC2 cells, unlike alphaTC1-6 cells, express low levels of PC1/3 that lead to the generation of glicentin as well as low amounts of oxyntomodulin, GLP-1, truncated GLP-1, and N-terminally extended GLP-2 [8].

Chemical compound and disease context of Glp2r


Biological context of Glp2r


Anatomical context of Glp2r


Associations of Glp2r with chemical compounds

  • METHODS: In 210 female C57bl mice, colonic tumours were initially induced with the methylating carcinogen 1,2-dimethylhydrazine (DMH) and mice were then treated with GLP-2 [2].
  • In contrast, absorption of leucine plus triolein was increased after duodenal administration in GLP-2-treated mice (P < 0.01-0.001) [14].
  • Oral or duodenal administration of glucose or maltose did not reveal any differences in the ability of GLP-2-treated mice to absorb these nutrients, possibly because of decreases in expression of the glucose transporters sodium-dependent glucose transporter-1 (SGLT-1) and GLUT-2 [14].

Other interactions of Glp2r

  • New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2 [15].
  • These findings strongly suggest that PC1 is essential for intestinal proglucagon processing in vivo and, thereby, plays an important role in production of the incretin hormone GLP-1 and the intestinotrophic hormone GLP-2 [16].
  • Proglucagon (proG) is differentially processed in the A cells of the pancreas to yield glucagon, and in the L cells of the intestine to generate glicentin, oxyntomodulin, the incretin glucagon-like peptide (GLP)-1(7-36NH2) and the intestinotropin GLP-2 [17].
  • The purpose of our study was to compare the trophic effects of GLP-2 with those of neurotensin (NT), a potent gut trophic factor [18].

Analytical, diagnostic and therapeutic context of Glp2r


  1. The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice. Dubé, P.E., Forse, C.L., Bahrami, J., Brubaker, P.L. Gastroenterology (2006) [Pubmed]
  2. Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Thulesen, J., Hartmann, B., Hare, K.J., Kissow, H., Ørskov, C., Holst, J.J., Poulsen, S.S. Gut (2004) [Pubmed]
  3. Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV. Geier, M.S., Tenikoff, D., Yazbeck, R., McCaughan, G.W., Abbott, C.A., Howarth, G.S. J. Cell. Physiol. (2005) [Pubmed]
  4. Stress impairs murine intestinal barrier function: improvement by glucagon-like peptide-2. Cameron, H.L., Perdue, M.H. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  5. Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. Tsai, C.H., Hill, M., Asa, S.L., Brubaker, P.L., Drucker, D.J. Am. J. Physiol. (1997) [Pubmed]
  6. Mucosal adaptation to enteral nutrients is dependent on the physiologic actions of glucagon-like peptide-2 in mice. Shin, E.D., Estall, J.L., Izzo, A., Drucker, D.J., Brubaker, P.L. Gastroenterology (2005) [Pubmed]
  7. Modulation of specific intestinal epithelial progenitors by enteric neurons. Bjerknes, M., Cheng, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets. Webb, G.C., Dey, A., Wang, J., Stein, J., Milewski, M., Steiner, D.F. J. Biol. Chem. (2004) [Pubmed]
  9. Deficiency of the intestinal growth factor, glucagon-like peptide 2, in the colon of SCID mice with inflammatory bowel disease induced by transplantation of CD4+ T cells. Schmidt, P.T., Hartmann, B., Bregenholt, S., Hoist, J.J., Claesson, M.H. Scand. J. Gastroenterol. (2000) [Pubmed]
  10. Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells. Lovshin, J.A., Huang, Q., Seaberg, R., Brubaker, P.L., Drucker, D.J. Endocrinology (2004) [Pubmed]
  11. X-chromosome inactivation in differentiating mouse embryonic stem cells carrying X-linked GFP and lacZ transgenes. Farivar, S., Yamaguchi, S., Sugimoto, M., Takagi, N. Int. J. Dev. Biol. (2004) [Pubmed]
  12. Uncoupling protein 2 involved in protection of glucagon-like peptide 2 in small intestine with ischemia-reperfusion injury in mice. Guan, L., Gong, D., Tian, N., Zou, Y. Dig. Dis. Sci. (2005) [Pubmed]
  13. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. Montrose-Rafizadeh, C., Yang, H., Wang, Y., Roth, J., Montrose, M.H., Adams, L.G. J. Cell. Physiol. (1997) [Pubmed]
  14. Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2. Brubaker, P.L., Izzo, A., Hill, M., Drucker, D.J. Am. J. Physiol. (1997) [Pubmed]
  15. New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. Drucker, D.J., Lovshin, J., Baggio, L., Nian, M., Adatia, F., Boushey, R.P., Liu, Y., Saleh, J., Yusta, B., Scrocchi, L. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  16. Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Ugleholdt, R., Zhu, X., Deacon, C.F., Ørskov, C., Steiner, D.F., Holst, J.J. Endocrinology (2004) [Pubmed]
  17. Proglucagon processing in an islet cell line: effects of PC1 overexpression and PC2 depletion. Dhanvantari, S., Brubaker, P.L. Endocrinology (1998) [Pubmed]
  18. Glucagon-like peptide 2 is a potent growth factor for small intestine and colon. Litvak, D.A., Hellmich, M.R., Evers, B.M., Banker, N.A., Townsend, C.M. J. Gastrointest. Surg. (1998) [Pubmed]
  19. Teduglutide ([Gly2]GLP-2) protects small intestinal stem cells from radiation damage. Booth, C., Booth, D., Williamson, S., Demchyshyn, L.L., Potten, C.S. Cell Prolif. (2004) [Pubmed]
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