Disease relevance of Allc

• The mouse mRNA seems capable of encoding a functional allantoicase, therefore we expressed the Xenopus and mouse allantoicases (MAlc and XAlc, respectively) in Escherichia coli and characterized the recombinant enzymes [1].

High impact information on Allc

• Allantoicase is an enzyme involved in uric acid degradation [1].
• Among the tested tissues, only testis possesses the allantoicase transcript [2].
• In mammals, the end product of this catabolic pathway is allantoin and, therefore, no allantoicase should be present in mouse tissues [2].
• Surprisingly, we have found an expressed sequence tag (EST) from mouse testis with high similarity to allantoicase [2].
• In this study, the antiproliferative activity of a 0.05% alclometasone ointment (Alc, Delonal) on the epidermis of the mouse tail was investigated [3].

Associations of Allc with chemical compounds

• We have found that Alc thins the epidermis to approximately the same extent as hydrocortisone acetate (1%), but has an extremely slighter epidermal thinning effect than betamethasone (betametasone-17,21-dipropionate, 0.064%, Diprosis) [3].

Analytical, diagnostic and therapeutic context of Allc

• Molecular cloning of mouse allantoicase cDNA [2].

References