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Gene Review

Pgf  -  placental growth factor

Rattus norvegicus

Synonyms: PlGF, Placenta growth factor, Plgf
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Disease relevance of Pgf

  • Chronic hypoxia significantly decreases the circulating levels of PlGF (P < .001) independent of L-NAME treatment [1].
  • Conclusions: Intramyocardial delivery of PlGF following a large myocardial infarction enhanced border zone angiogenesis, attenuated adverse ventricular remodeling, and preserved cardiac function [2].

High impact information on Pgf

  • In contrast, pure PlGF homodimers are mitogenic for endothelial cells only at high, possibly non-physiologic concentrations; thus the biological relevance of their mitogenic activity for these cells is not obvious [3].
  • Methods: Wistar rats underwent high proximal ligation of the left anterior descending coronary artery and direct injection of PlGF (n = 10) or saline as a control (n = 10) into the myocardium bordering the ischemic area [2].
  • Using in situ hybridization histochemistry, positive cells of PlGF mRNA were detected in chorionic villi [4].
  • RT-PCR analysis showed that the expression level of PlGF mRNA increased as gestation advanced [4].
  • The expression pattern of PlGF mRNA in rat placenta during pregnancy demonstrates that PlGF plays a functional role for placental growth and fetal development during mid-late pregnancy [4].

Biological context of Pgf

  • CONCLUSION: Chronic NO inhibition as well as hypoxia induce fetal growth restriction and significantly change maternal circulating levels of sFlt-1 and PlGF, but not of VEGF [1].
  • In particular, the density and number of positive signals of PlGF mRNA was significantly increased as gestation advanced [4].

Anatomical context of Pgf


Analytical, diagnostic and therapeutic context of Pgf


  1. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. Bahtiyar, M.O., Buhimschi, C., Ravishankar, V., Copel, J., Norwitz, E., Julien, S., Guller, S., Buhimschi, I.A. Am. J. Obstet. Gynecol. (2007) [Pubmed]
  2. Placental growth factor provides a novel local angiogenic therapy for ischemic cardiomyopathy. Kolakowski, S., Berry, M.F., Atluri, P., Grand, T., Fisher, O., Moise, M.A., Cohen, J., Hsu, V., Woo, Y.J. Journal of cardiac surgery. (2006) [Pubmed]
  3. Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. DiSalvo, J., Bayne, M.L., Conn, G., Kwok, P.W., Trivedi, P.G., Soderman, D.D., Palisi, T.M., Sullivan, K.A., Thomas, K.A. J. Biol. Chem. (1995) [Pubmed]
  4. Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy. Choi, W.S., Cho, G.J., Won, C.K., Koh, P.O. J. Vet. Sci. (2005) [Pubmed]
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