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Olig3  -  oligodendrocyte transcription factor 3

Mus musculus

Synonyms: Bhlhb7, Class B basic helix-loop-helix protein 7, Oligo3, Oligodendrocyte transcription factor 3, Oligodendrocyte-specific bHLH transcription factor 3, ...
 
 
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High impact information on Olig3

  • The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord [1].
  • We show here that the basic helix-loop-helix (bHLH) gene Olig3 is expressed in progenitor cells that generate class A (dI1-dI3) neurons and that Olig3 is an important factor in the development of these neuronal cell types [1].
  • Olig1 or Olig3, other family members, were expressed in the descendent cells that should have expressed Olig2 [2].
  • Some of the dorsal Olig3 lineage cells co-expressed Islet1/2, Math1, or Brn3a, markers for dorsal interneuron [3].
  • These findings suggest that dorsal Olig3 cells contribute to dorsal midline cells and commissural interneurons at intermediate and ventral levels [3].
 

Anatomical context of Olig3

  • In E11.5 spinal cord, Olig3 was transiently expressed in the lateral margin of the subventricular zone as three ventral clusters at the level of the p3, p2 and p0 domains, as well as in the dorsal neural tube [4].
  • 5. Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development [4].
  • Olig3 was first detected in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord [4].
 

Other interactions of Olig3

  • Olig3 was isolated as a third member of Olig family, but its precise expression pattern is poorly understood [4].
 

Analytical, diagnostic and therapeutic context of Olig3

References

  1. The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. Müller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M., Birchmeier, C. Genes Dev. (2005) [Pubmed]
  2. The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K., Nabeshima, Y. Curr. Biol. (2002) [Pubmed]
  3. Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord. Ding, L., Takebayashi, H., Watanabe, K., Ohtsuki, T., Tanaka, K.F., Nabeshima, Y., Chisaka, O., Ikenaka, K., Ono, K. Dev. Dyn. (2005) [Pubmed]
  4. Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube. Takebayashi, H., Ohtsuki, T., Uchida, T., Kawamoto, S., Okubo, K., Ikenaka, K., Takeichi, M., Chisaka, O., Nabeshima, Y. Mech. Dev. (2002) [Pubmed]
 
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