Disease relevance of Maged1

• Finally, co-expression of NRAGE and cytosolic PrP(C) affected mitochondrial membrane potential in neuroblastoma cells [1].
• We have cloned the homology region between Dlxin-1 and necdin from mouse melanoma cells [2].
• Characteristically, lymphomas, leukaemias, adenocarcinomas, and carcinomas did not express Dlxin-1 [2].

High impact information on Maged1

• Disruption of NRAGE or any other member of the noncanonical signaling cascaded is sufficient to block p38 activation and thus the proapoptotic signals generated through BMP exposure [3].
• We demonstrate that BMP signaling is required for the induction of apoptosis of neural progenitors and that NRAGE is a mandatory component of the signaling cascade [3].
• MAGE-D1 (NRAGE, Dlxin-1) interacts with the Dlx/Msx family homeodomain proteins via an interspersed hexapeptide repeat domain distinct from the homology domain [4].
• Interaction of PrP with NRAGE, a protein involved in neuronal apoptosis [1].
• Our data support previously characterized roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development [5].

Biological context of Maged1

• Here we have examined the temporal and spatial expression patterns of NRAGE over the course of murine embryogenesis to determine whether NRAGE's expression is consistent with its proposed functions [5].
• Cloning and tissue-specific gene expression studies with Dlxin-1, a newly identified transcriptional activator [2].

Other interactions of Maged1

• NRAGE possesses the ability to bind and function with the TAK1-TAB1-XIAP complex facilitating the activation of p38 [3].
• Dlxin-1, a unique member of the necdin/melanoma associated antigen gene (MAGE) family, is a novel protein that binds Dlxin-5 and regulates its transcriptional function [2].
• During early CNS development, NRAGE protein is expressed throughout the neural tube, but by later stages of neurogenesis, NRAGE protein is restricted within the ventricular zone, subplate and cortical plate [5].

References