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Gene Review: 

hcaB  -  2,3-dihydroxy-2,3-dihydrophenylpropionate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2538, JW2525, phdD, yfhX
 
 
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Disease relevance of hcaB

  • RESULTS: The pGI1 plasmid of Bacillus thuringiensis H1.1 harbours a group of two genes, one showing similarities with the Doc toxin of the phd-doc toxin-antitoxin system, potentially coding for a toxin-antitoxin system [1].
 

High impact information on hcaB

  • The genes responsible for the degradation of phenanthrene to o-phthalate (phd) were found by Southern hybridization to reside on the chromosome [2].
  • Sequence comparisons revealed that while hcaA1A2CD genes encode the four subunits of the 3-phenylpropionate dioxygenase, the hcaB gene codes for the corresponding cis-dihydrodiol dehydrogenase [3].
 

Associations of hcaB with chemical compounds

  • The genetic organization of the phd genes, the phylogenetically diverged positions of these genes, and an unusual type of ferredoxin component suggest phenanthrene dioxygenase in Nocardioides sp. strain KP7 to be a new class of aromatic ring-hydroxylating dioxygenases [2].

References

  1. TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system. Fico, S., Mahillon, J. BMC Genomics (2006) [Pubmed]
  2. A novel phenanthrene dioxygenase from Nocardioides sp. Strain KP7: expression in Escherichia coli. Saito, A., Iwabuchi, T., Harayama, S. J. Bacteriol. (2000) [Pubmed]
  3. Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. Díaz, E., Ferrández, A., García, J.L. J. Bacteriol. (1998) [Pubmed]
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