Disease relevance of uup

• Characterization of the uup locus and its role in transposon excisions and tandem repeat deletions in Escherichia coli [1].
• The uup gene product shares extensive homology with the deduced sequences of two proteins of Haemophilus influenzae [2].
• New class of mutations in Escherichia coli (uup) that affect precise excision of insertion elements and bacteriophage Mu growth [3].

High impact information on uup

• The promoter for uup was mapped upstream of ycbY by primer extension analysis on cellular RNA, and assays of reporter gene expression indicated that it is a moderately active, constitutive promoter [1].
• Identification and characterization of ssb and uup mutants with increased frequency of precise excision of transposon Tn10 derivatives: nucleotide sequence of uup in Escherichia coli [2].
• The nucleotide sequence of uup was determined, and the gene was inferred to encode a 625-amino-acid hydrophilic protein that belongs to the superfamily of ABC-domain proteins (with two pairs of the Walker A and B motifs), which are postulated to be involved in coupling ATP hydrolysis with other biological processes [2].

References