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Gene Review:

emtA - lytic murein endotransglycosylase E

Escherichia coli str. K-12 substr. MG1655

Mann, P.A. et al., Kraft, A.R. et al.

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High impact information on emtA

Overexpression of the emtA gene did not result in bacteriolysis in vivo, but the enzyme was shown to hydrolyze glycan strands isolated from murein by amidase treatment [1].

Analytical, diagnostic and therapeutic context of emtA

The resistance determinant was cloned from strain 9631355; sequence alignments suggested it was a methyltransferase and therefore it was designated emtA for evernimicin methyltransferase [2].

References

Membrane-bound lytic endotransglycosylase in Escherichia coli. Kraft, A.R., Templin, M.F., Höltje, J.V. J. Bacteriol. (1998) [Pubmed]
EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance. Mann, P.A., Xiong, L., Mankin, A.S., Chau, A.S., Mendrick, C.A., Najarian, D.J., Cramer, C.A., Loebenberg, D., Coates, E., Murgolo, N.J., Aarestrup, F.M., Goering, R.V., Black, T.A., Hare, R.S., McNicholas, P.M. Mol. Microbiol. (2001) [Pubmed]

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