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Gene Review

sufB  -  component of SufBCD Fe-S cluster assembly...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1679, JW5273, ynhE
 
 
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High impact information on sufB

  • Of particular interest are the sufB, sufC and sufD genes, which are conserved among Eubacteria, Archaea, plants and parasites [1].
  • We speculate that one of these, called ycf24 in plants and sufB in bacteria, is tied to an essential "dark" reaction of the organelle--fatty acid biosynthesis. "Ball-park" clues to the function of bacterial suf genes have emerged only recently and point to the areas of iron homeostasis, [Fe-S] cluster formation and oxidative stress [2].
  • The sufB and sufC genes that always occur together in bacteria are also found in plants, and even the malaria parasite, associated with the plastid organelle [3].

References

  1. SufC: an unorthodox cytoplasmic ABC/ATPase required for [Fe-S] biogenesis under oxidative stress. Nachin, L., Loiseau, L., Expert, D., Barras, F. EMBO J. (2003) [Pubmed]
  2. Parasite plastids: maintenance and functions. Wilson, R.J., Rangachari, K., Saldanha, J.W., Rickman, L., Buxton, R.S., Eccleston, J.F. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2003) [Pubmed]
  3. SufC hydrolyzes ATP and interacts with SufB from Thermotoga maritima. Rangachari, K., Davis, C.T., Eccleston, J.F., Hirst, E.M., Saldanha, J.W., Strath, M., Wilson, R.J. FEBS Lett. (2002) [Pubmed]
 
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