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Gene Review:

prc - carboxy-terminal protease for penicillin...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1829, JW1819, tsp

Hara, H. et al., Seoane, A. et al., Chen, C. et al., Kunte, H.J. et al., Bass, S. et al., et al.

Tadokoro, Hayashi, Kishimoto, Makino, Fujisaki, Nishimura,

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Disease relevance of prc

Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA [1].

High impact information on prc

Locus proQ is upstream from prc (tsp) at 41.2 centisomes on the genetic map [2].
The proQ220::Tn5 and prc phenotypes were different, however [2].
Complementation studies with the prc gene on plasmids showed complete recovery of parental levels of susceptibility to all drugs except chloramphenicol, with which only partial reversion to wild-type levels was observed [3].
DNA sequencing analysis of the prc gene region identified an open reading frame, with two possible translational starts 6 bp apart from each other, that could code for a product with a calculated molecular weight of 76,667 or 76,432 [4].
The prc gene, which is involved in cleavage of the C-terminal peptide from the precursor form of penicillin-binding protein 3 (PBP 3) of Escherichia coli, was cloned and mapped at 40.4 min on the chromosome [4].

Biological context of prc

The results also show that spr, a suppressor of growth defects in prc strains, is required for a prc mutant to survive throughout high cell density fermentations [5].

Other interactions of prc

Escherichia coli spr (suppressor of prc) mutants and nlpI mutants show thermosensitive growth [6].

References

Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA. Bass, S., Gu, Q., Christen, A. J. Bacteriol. (1996) [Pubmed]
Protein ProQ influences osmotic activation of compatible solute transporter ProP in Escherichia coli K-12. Kunte, H.J., Crane, R.A., Culham, D.E., Richmond, D., Wood, J.M. J. Bacteriol. (1999) [Pubmed]
Multiple antibiotic susceptibility associated with inactivation of the prc gene. Seoane, A., Sabbaj, A., McMurry, L.M., Levy, S.B. J. Bacteriol. (1992) [Pubmed]
Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3. Hara, H., Yamamoto, Y., Higashitani, A., Suzuki, H., Nishimura, Y. J. Bacteriol. (1991) [Pubmed]
High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain. Chen, C., Snedecor, B., Nishihara, J.C., Joly, J.C., McFarland, N., Andersen, D.C., Battersby, J.E., Champion, K.M. Biotechnol. Bioeng. (2004) [Pubmed]
Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease. Tadokoro, A., Hayashi, H., Kishimoto, T., Makino, Y., Fujisaki, S., Nishimura, Y. J. Biochem. (2004) [Pubmed]

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