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Gene Review

fliD  -  flagellar filament capping protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1923, JW1909, flbC, rfs
 
 
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Disease relevance of fliD

 

High impact information on fliD

  • Flagellar growth does not occur in fliD-deficient mutants because flagellin monomers transported through the central channel of the flagellum leak out without polymerizing at the distal end [2].
  • In region III, a previously unidentified gene flbC was located between hag and flaN [3].
  • Previous sequence analysis of this operon in both organisms has revealed that the fliD gene constitutes an operon together with two additional genes, fliS and fliT [1].
 

Other interactions of fliD

  • We have found that fliD, the last known gene in region IIIa, is immediately followed by two additional genes, both necessary for flagellation, which we have designated fliS and fliT [4].

References

  1. Functional analysis of the flagellar genes in the fliD operon of Salmonella typhimurium. Yokoseki, T., Kutsukake, K., Ohnishi, K., Iino, T. Microbiology (Reading, Engl.) (1995) [Pubmed]
  2. Assembly characteristics of flagellar cap protein HAP2 of Salmonella: decamer and pentamer in the pH-sensitive equilibrium. Imada, K., Vonderviszt, F., Furukawa, Y., Oosawa, K., Namba, K. J. Mol. Biol. (1998) [Pubmed]
  3. Definition of additional flagellar genes in Escherichia coli K12. Komeda, Y., Kutsukake, K., Iino, T. Genetics (1980) [Pubmed]
  4. Subdivision of flagellar region III of the Escherichia coli and Salmonella typhimurium chromosomes and identification of two additional flagellar genes. Kawagishi, I., Müller, V., Williams, A.W., Irikura, V.M., Macnab, R.M. J. Gen. Microbiol. (1992) [Pubmed]
 
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