Disease relevance of gsk

• Cloning and characterization of the gsk gene encoding guanosine kinase of Escherichia coli [1].

High impact information on gsk

• The remaining reading frames had homology to galE, rol, and gsk [2].
• N-terminal sequence and amino acid composition analyses of the 43,500-M(r) polypeptide band confirmed the correct reading frame assignment and the identity of this band as the gsk gene product [1].
• Strains harboring the gsk gene on multicopy plasmids overexpressed both guanosine and inosine kinase activities [1].
• The Escherichia coli gsk gene encoding guanosine kinase was cloned from the Kohara gene library by complementation of the E. coli gsk-1 mutant allele [1].
• Thus the rfb gene cluster of YeO8 is located between the adk-hemH and gsk loci, and the order is adk-hemH-rfb-rfc-gsk in the chromosome [3].

Associations of gsk with chemical compounds

• Alternatively, the gsk (guanosine-inosine kinase gene) disruption caused a considerable amount of guanosine accumulation together with a slight increase in the inosine productivity [4].

References