Disease relevance of nmpC

• Expression of the nmpC gene of Escherichia coli K-12 is modulated by external pH. Identification of cis-acting regulatory sequences involved in this regulation [1].
• Structure of the lc and nmpC outer membrane porin protein genes of lambdoid bacteriophage [2].

High impact information on nmpC

• Blot hybridization detected no mRNA transcripts from the wild-type nmpC gene, although transcripts were readily detected from the lc gene in PA-2 lysogens and from the nmpC mutant which has excised the IS5 [2].
• The lc gene of the lambdoid bacteriophage PA-2 and the nmpC gene located on a defective lambdoid prophage in the 12-min region of the Escherichia coli K12 chromosome have been sequenced [2].
• Plasmid expression experiments using lc-nmpC hybrid genes show that it is the presence of the IS5 insertion which prevents expression of the porin in wild-type E. coli K12 [2].
• Using a set of gene fusions generated with TnphoA, we previously identified the phmA locus, whose expression is modulated as a function of external pH (pHo) [1].
• Identification and characterization of two quiescent porin genes, nmpC and ompN, in Escherichia coli BE [3].

Chemical compound and disease context of nmpC

• In wild-type strains of E. coli K12, the nmpC gene is not expressed and contains an IS5 insertion near the 3' end of the coding region [2].

Associations of nmpC with chemical compounds

• This indicates that IS5 affects the production or stability of transcripts from the adjacent nmpC gene [2].

Other interactions of nmpC

• The new proteins produced in strains carrying nmpA, nmpB, or nmpC mutations did not cross-react with antiserum against a mixture of proteins 1a and 1b, or with antiserum against phage-directed protein 2 [4].

References