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Gene Review

fumA  -  fumarate hydratase (fumarase A), aerobic...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1607, JW1604
 
 
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Disease relevance of fumA

  • The fumB gene of Escherichia coli, which complements the fumarase deficiency of a fumA mutant when present in multiple copies, has been located at 93.5 min in the E. coli linkage map and its product has been identified as a polypeptide of 61 kDal [1].
 

High impact information on fumA

  • The DNA fragment also contains the 5' end of the manA gene encoding mannose 6-phosphate isomerase, which is transcribed with the opposite polarity to fumA [2].
  • The length of the fumA transcript was estimated as 1760 +/- 15 nucleotides and the fumA coding region of 1647 base pairs (549 codons) was identified [2].
  • The amino acid sequences of their NH2-terminals suggest that the two enzymes are the products of the fumA gene (FUMA) and fumC gene (FUMC), respectively [3].
  • If so, the fumB gene may encode a related enzyme or activator that can replace the fumA function when amplified [1].

References

  1. The fumarase genes of Escherichia coli: location of the fumB gene and discovery of a new gene (fumC). Guest, J.R., Miles, J.S., Roberts, R.E., Woods, S.A. J. Gen. Microbiol. (1985) [Pubmed]
  2. Complete nucleotide sequence of the fumarase gene fumA, of Escherichia coli. Miles, J.S., Guest, J.R. Nucleic Acids Res. (1984) [Pubmed]
  3. Purification and characterization of two types of fumarase from Escherichia coli. Ueda, Y., Yumoto, N., Tokushige, M., Fukui, K., Ohya-Nishiguchi, H. J. Biochem. (1991) [Pubmed]
 
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