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Gene Review

gltX  -  glutamyl-tRNA synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2394, JW2395
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Disease relevance of gltX


High impact information on gltX


Chemical compound and disease context of gltX


Biological context of gltX


Associations of gltX with chemical compounds

  • Neither glutamyl-tRNA synthetase nor GSA aminotransferase activity was affected by hemin concentrations up to 10 and 30 microM, respectively, and neither activity was affected by protochlorophyllide concentrations up to 2 microM [9].
  • Conformation change of tRNAGlu in the complex with glutamyl-tRNA synthetase is required for the specific binding of L-glutamate [13].

Other interactions of gltX

  • We analyzed the nine mutants genetically and found that they could be classified into three complementation groups, pktA, pktB and pktC, which corresponded to three genes, ileS, gltX and asnS, encoding isoleucyl-, glutamyl- and asparaginyl-tRNA synthetases, respectively [14].

Analytical, diagnostic and therapeutic context of gltX


  1. Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. Brun, Y.V., Breton, R., Lanouette, P., Lapointe, J. J. Mol. Biol. (1990) [Pubmed]
  2. Expression of the glutamyl-tRNA synthetase gene from the cyanobacterium Synechococcus sp PCC 7942 depends on nitrogen availability and the global regulator NtcA. Luque, I., Contreras, A., Zabulon, G., Herrero, A., Houmard, J. Mol. Microbiol. (2002) [Pubmed]
  3. Glutamyl-tRNA synthetase from Thermus thermophilus HB8. Molecular cloning of the gltX gene and crystallization of the overproduced protein. Nureki, O., Suzuki, K., Hara-Yokoyama, M., Kohno, T., Matsuzawa, H., Ohta, T., Shimizu, T., Morikawa, K., Miyazawa, T., Yokoyama, S. Eur. J. Biochem. (1992) [Pubmed]
  4. In vivo and in vitro processing of the Bacillus subtilis transcript coding for glutamyl-tRNA synthetase, serine acetyltransferase, and cysteinyl-tRNA synthetase. Pelchat, M., Lapointe, J. RNA (1999) [Pubmed]
  5. Co-transcription of Rhizobium meliloti lysyl-tRNA synthetase and glutamyl-tRNA synthetase genes. Pelchat, M., Gagnon, Y., Laberge, S., Lapointe, J. FEBS Lett. (1999) [Pubmed]
  6. The zinc-binding site of Escherichia coli glutamyl-tRNA synthetase is located in the acceptor-binding domain. Studies by extended x-ray absorption fine structure, molecular modeling, and site-directed mutagenesis. Liu, J., Gagnon, Y., Gauthier, J., Furenlid, L., L'Heureux, P.J., Auger, M., Nureki, O., Yokoyama, S., Lapointe, J. J. Biol. Chem. (1995) [Pubmed]
  7. Clustering and co-transcription of the Bacillus subtilis genes encoding the aminoacyl-tRNA synthetases specific for glutamate and for cysteine and the first enzyme for cysteine biosynthesis. Gagnon, Y., Breton, R., Putzer, H., Pelchat, M., Grunberg-Manago, M., Lapointe, J. J. Biol. Chem. (1994) [Pubmed]
  8. Glutamyl-tRNA synthetase of Escherichia coli. Isolation and primary structure of the gltX gene and homology with other aminoacyl-tRNA synthetases. Breton, R., Sanfaçon, H., Papayannopoulos, I., Biemann, K., Lapointe, J. J. Biol. Chem. (1986) [Pubmed]
  9. Separation and partial characterization of enzymes catalyzing delta-aminolevulinic acid formation in Synechocystis sp. PCC 6803. Rieble, S., Beale, S.I. Arch. Biochem. Biophys. (1991) [Pubmed]
  10. Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. Bernier, S., Dubois, D.Y., Habegger-Polomat, C., Gagnon, L.P., Lapointe, J., Chênevert, R. Journal of enzyme inhibition and medicinal chemistry. (2005) [Pubmed]
  11. Closely spaced and divergent promoters for an aminoacyl-tRNA synthetase gene and a tRNA operon in Escherichia coli. Transcriptional and post-transcriptional regulation of gltX, valU and alaW. Brun, Y.V., Sanfaçon, H., Breton, R., Lapointe, J. J. Mol. Biol. (1990) [Pubmed]
  12. Cloning of the glutamyl-tRNA synthetase (gltX) gene from Pseudomonas aeruginosa. Franklund, C.V., Goldberg, J.B. J. Bacteriol. (1999) [Pubmed]
  13. Conformation change of tRNAGlu in the complex with glutamyl-tRNA synthetase is required for the specific binding of L-glutamate. Hara-Yokoyama, M., Yokoyama, S., Miyazawa, T. Biochemistry (1986) [Pubmed]
  14. Isolation of temperature-sensitive aminoacyl-tRNA synthetase mutants from an Escherichia coli strain harboring the pemK plasmid. Masuda, Y., Tsuchimoto, S., Nishimura, A., Ohtsubo, E. Mol. Gen. Genet. (1993) [Pubmed]
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