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Gene Review:

hcaE - 3-phenylpropionate dioxygenase, large...

Escherichia coli str. K-12 substr. MG1655

Turlin, E. et al., Turlin, E. et al.

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Disease relevance of hcaE

Expression of the hcaA gene product, which is involved in 3-phenylpropionate catabolism in Escherichia coli, was positively regulated by HcaR, a regulatory protein similar to members of the LysR regulators family [1].

High impact information on hcaE

Using gel retardation, the HcaR binding site was estimated to be located about -70 to -55 bp upstream of the hcaA transcription start site [2].
Remarkably, the expression of hcaA in the presence of 3-phenylpropionate was sharply and transiently induced at the end of the exponential growth phase [1].

References

Regulation of the early steps of 3-phenylpropionate catabolism in Escherichia coli. Turlin, E., Perrotte-piquemal, M., Danchin, A., Biville, F. J. Mol. Microbiol. Biotechnol. (2001) [Pubmed]
3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Turlin, E., Sismeiro, O., Le Caer, J.P., Labas, V., Danchin, A., Biville, F. Res. Microbiol. (2005) [Pubmed]

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