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Gene Review:

norW - NADH:flavorubredoxin oxidoreductase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2706, JW2681, ygaL, ygbD

Gardner, A.M. et al., da Costa, P.N. et al., Silaghi-Dumitrescu, R. et al., Thorndycroft, F.H. et al., Gardner, A.M. et al., et al.

Gardner, Gessner, Gardner,

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Disease relevance of norW

A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin [1].
A flavo-diiron protein from Desulfovibrio vulgaris with oxidase and nitric oxide reductase activities. Evidence for an in vivo nitric oxide scavenging function [2].

High impact information on norW

Exposure of E. coli to sub-micromolar NO levels under anaerobic conditions rapidly induced transcription of the NO reductase (NOR) structural genes, norV and norW, as monitored by lac gene fusions [3].
We suggest designation of the ygaA-ygaK-ygbD gene cluster as the norRVW modulon for NO reduction and detoxification [4].
Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control [5].
A new assay for nitric oxide reductase reveals two conserved glutamate residues form the entrance to a proton-conducting channel in the bacterial enzyme [6].

References

A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin. Gomes, C.M., Giuffrè, A., Forte, E., Vicente, J.B., Saraiva, L.M., Brunori, M., Teixeira, M. J. Biol. Chem. (2002) [Pubmed]
A flavo-diiron protein from Desulfovibrio vulgaris with oxidase and nitric oxide reductase activities. Evidence for an in vivo nitric oxide scavenging function. Silaghi-Dumitrescu, R., Ng, K.Y., Viswanathan, R., Kurtz, D.M. Biochemistry (2005) [Pubmed]
Regulation of the nitric oxide reduction operon (norRVW) in Escherichia coli. Role of NorR and sigma54 in the nitric oxide stress response. Gardner, A.M., Gessner, C.R., Gardner, P.R. J. Biol. Chem. (2003) [Pubmed]
Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli. Gardner, A.M., Helmick, R.A., Gardner, P.R. J. Biol. Chem. (2002) [Pubmed]
Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control. da Costa, P.N., Teixeira, M., Saraiva, L.M. FEMS Microbiol. Lett. (2003) [Pubmed]
A new assay for nitric oxide reductase reveals two conserved glutamate residues form the entrance to a proton-conducting channel in the bacterial enzyme. Thorndycroft, F.H., Butland, G., Richardson, D.J., Watmough, N.J. Biochem. J. (2007) [Pubmed]

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