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Gene Review:

norR - anaerobic nitric oxide reductase DNA...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2704, JW5843, ygaA

Tucker, N.P. et al., Gardner, A.M. et al., da Costa, P.N. et al., Hutchings, M.I. et al., Tucker, N.P. et al.

Tucker, D'autréaux, Spiro, Dixon,

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Disease relevance of norR

In Escherichia coli, ygaA encodes a transcription regulator (b2709) controlling anaerobic NO reduction and detoxification [1].

High impact information on norR

We suggest designation of the ygaA-ygaK-ygbD gene cluster as the norRVW modulon for NO reduction and detoxification [1].
In the present paper, we show that disruption of any one of the three GT-(N(7))-AC NorR binding sites in the norR-norVW intergenic region prevents both activation of norVW expression and autogenous repression of the norR promoter by NorR [2].
NorR binds co-operatively to three enhancer sites to regulate transcription of both norVW and the divergently transcribed norR gene [2].
Transcription of the putative transcriptional activator of flavorubredoxin, ygaA, is also regulated by the absence of oxygen and the presence of nitrite [3].

Biological context of norR

Three binding sites for NorR and two integration host factor binding sites were identified in the norR-norV intergenic region [4].

Associations of norR with chemical compounds

Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR [5].

References

Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli. Gardner, A.M., Helmick, R.A., Gardner, P.R. J. Biol. Chem. (2002) [Pubmed]
Mechanism of transcriptional regulation by the Escherichia coli nitric oxide sensor NorR. Tucker, N.P., D'autréaux, B., Spiro, S., Dixon, R. Biochem. Soc. Trans. (2006) [Pubmed]
Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control. da Costa, P.N., Teixeira, M., Saraiva, L.M. FEMS Microbiol. Lett. (2003) [Pubmed]
DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria. Tucker, N.P., D'Autréaux, B., Studholme, D.J., Spiro, S., Dixon, R. J. Bacteriol. (2004) [Pubmed]
The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species. Hutchings, M.I., Mandhana, N., Spiro, S. J. Bacteriol. (2002) [Pubmed]

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