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Gene Review:

hypD - hydrogenase maturation protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2724, JW2699, hydF

Sankar, P. et al., King, P.W. et al.

King, Posewitz, Ghirardi, Seibert,

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Disease relevance of hypD

Hydrogen metabolism in Escherichia coli: biochemical and genetic evidence for a hydF gene [1].
A more stable [FeFe] hydrogenase expression system has been achieved in E. coli by cloning and coexpression of hydE, hydF, and hydG from the bacterium Clostridium acetobutylicum [2].

High impact information on hypD

This gene, termed hydF, mapped at 59 min in the E. coli chromosome and resided next to the hydB gene [1].
Expression of the hydF operon was enhanced by anaerobic growth conditions [1].

References

Hydrogen metabolism in Escherichia coli: biochemical and genetic evidence for a hydF gene. Sankar, P., Shanmugam, K.T. J. Bacteriol. (1988) [Pubmed]
Functional studies of [FeFe] hydrogenase maturation in an Escherichia coli biosynthetic system. King, P.W., Posewitz, M.C., Ghirardi, M.L., Seibert, M. J. Bacteriol. (2006) [Pubmed]

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