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Gene Review:

mazG - nucleoside triphosphate pyrophosphohydrolase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2775, JW2752

Zhang, J. et al., Bullions, L.C. et al., Saraswat, V. et al., Gross, M. et al.

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Disease relevance of mazG

A mazG deletion strain of E. coli was constructed by replacing the mazG gene with a kanamycin resistance gene [1].
Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity [2].

High impact information on mazG

On the same operon, downstream to the mazEF genes, we found another open reading frame, which was called mazG [3].
Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase [4].
Unlike mutT, a gene for another conserved nucleotide triphosphate pyrophosphohydrolase that functions as a mutator gene, the mazG deletion did not result in a mutator phenotype in E. coli [1].

References

MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. Zhang, J., Inouye, M. J. Bacteriol. (2002) [Pubmed]
Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity. Bullions, L.C., Méjean, V., Claverys, J.P., Bessman, M.J. J. Biol. Chem. (1994) [Pubmed]
MazG -- a regulator of programmed cell death in Escherichia coli. Gross, M., Marianovsky, I., Glaser, G. Mol. Microbiol. (2006) [Pubmed]
Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase. Saraswat, V., Massiah, M.A., Lopez, G., Amzel, L.M., Mildvan, A.S. Biochemistry (2002) [Pubmed]

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