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Gene Review:

tktA - transketolase 1, thiamine triphosphate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2930, JW5478, tkt

Chandran, S.S. et al., Lee, J.N. et al., Zhao, G. et al.

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Disease relevance of tktA

We show that a tktA tktB double mutant, which is devoid of the two known transketolase isoenzymes of Escherichia coli K-12, requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth [1].

High impact information on tktA

The impact of increased availability of phosphoenolpyruvate during shikimic acid biosynthesis has been examined in Escherichia coli K-12 constructs carrying plasmid-localized aroF(FBR) and tktA inserts encoding, respectively, feedback-insensitive 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase and transketolase [2].
Meanwhile, the amplified tktA gene significantly increased both PHB biosynthesis and cell growth as a result of the effective flow of glyceraldehyde-3-phosphate into acetyl-CoA along with the concomitant supplementation of NADPH [3].

References

An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth. Zhao, G., Winkler, M.E. J. Bacteriol. (1994) [Pubmed]
Phosphoenolpyruvate availability and the biosynthesis of shikimic acid. Chandran, S.S., Yi, J., Draths, K.M., von Daeniken, R., Weber, W., Frost, J.W. Biotechnol. Prog. (2003) [Pubmed]
Metabolic engineering of pentose phosphate pathway in Ralstoniaeutropha for enhanced biosynthesis of poly-beta-hydroxybutyrate. Lee, J.N., Shin, H.D., Lee, Y.H. Biotechnol. Prog. (2003) [Pubmed]

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