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Gene Review:

waaP - kinase that phosphorylates core heptose of...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3620, JW3605, rfaP

Anthony, K.G. et al., Yethon, J.A. et al., Klena, J.D. et al., Parker, C.T. et al., Stanley, P.L. et al.

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Disease relevance of rfaP

Complementation of Salmonella typhimurium rfa mutants with E. coli rfa restriction fragments indicated that the second and third genes in the block were rfaG and rfaP [1].
Loss of activity in the secreted form of Escherichia coli haemolysin caused by an rfaP lesion in core lipopolysaccharide assembly [2].

High impact information on rfaP

Transfer of all three plasmids was affected differently by mutations in the rfa (LPS) locus of the recipient cell, the F plasmid being most sensitive to mutations that affected rfaP gene expression which is responsible for the addition of pyrophosphorylethanolamine (PPEA) to heptose I of the inner core of the LPS [3].
In Escherichia coli, the waaP (rfaP) gene product was recently shown to be responsible for phosphorylation of the first heptose residue of the lipopolysaccharide (LPS) inner core region [4].
Partial sequencing of the rfa cluster of Salmonella typhimurium LT2 indicated a region of 336 bp between rfaP and rfaB in the site occupied by the rfaS gene in Escherichia coli K-12 [5].

References

Identification and sequences of the lipopolysaccharide core biosynthetic genes rfaQ, rfaP, and rfaG of Escherichia coli K-12. Parker, C.T., Pradel, E., Schnaitman, C.A. J. Bacteriol. (1992) [Pubmed]
Loss of activity in the secreted form of Escherichia coli haemolysin caused by an rfaP lesion in core lipopolysaccharide assembly. Stanley, P.L., Diaz, P., Bailey, M.J., Gygi, D., Juarez, A., Hughes, C. Mol. Microbiol. (1993) [Pubmed]
The role of the pilus in recipient cell recognition during bacterial conjugation mediated by F-like plasmids. Anthony, K.G., Sherburne, C., Sherburne, R., Frost, L.S. Mol. Microbiol. (1994) [Pubmed]
Salmonella enterica serovar typhimurium waaP mutants show increased susceptibility to polymyxin and loss of virulence In vivo. Yethon, J.A., Gunn, J.S., Ernst, R.K., Miller, S.I., Laroche, L., Malo, D., Whitfield, C. Infect. Immun. (2000) [Pubmed]
The rfaS gene, which is involved in production of a rough form of lipopolysaccharide core in Escherichia coli K-12, is not present in the rfa cluster of Salmonella typhimurium LT2. Klena, J.D., Pradel, E., Schnaitman, C.A. J. Bacteriol. (1993) [Pubmed]

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