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Gene Review

dapE  -  N-succinyl-diaminopimelate deacylase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2467, JW2456, msgB
 
 
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Disease relevance of dapE

 

High impact information on dapE

  • Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the dapE-encoded desuccinylase is required for the bacterial synthesis of lysine and meso-diaminopimelic acid [3].
  • Expression of the dapE gene was studied by monitoring amylomaltase activity in strains in which the malPQ operon was under the control of various fragments located upstream of the dapE gene [1].
  • The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE [5].
  • The msgB gene maps at approximately 53 min on the E. coli chromosome [5].
  • Consistent with this finding, the msgB null allele mutant is viable only when the growth medium is supplemented with diaminopimelic acid [5].
 

Biological context of dapE

References

  1. Cloning, characterization, and expression of the dapE gene of Escherichia coli. Bouvier, J., Richaud, C., Higgins, W., Bögler, O., Stragier, P. J. Bacteriol. (1992) [Pubmed]
  2. L,L-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine. McCoy, A.J., Adams, N.E., Hudson, A.O., Gilvarg, C., Leustek, T., Maurelli, A.T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism. Born, T.L., Zheng, R., Blanchard, J.S. Biochemistry (1998) [Pubmed]
  4. Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria. Cirillo, J.D., Weisbrod, T.R., Banerjee, A., Bloom, B.R., Jacobs, W.R. J. Bacteriol. (1994) [Pubmed]
  5. The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE. Wu, B., Georgopoulos, C., Ang, D. J. Bacteriol. (1992) [Pubmed]
 
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