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Gene Review

rpiB  -  ribose 5-phosphate isomerase B/allose 6...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4083, JW4051, alsB, alsI, yjcA
 
 
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Disease relevance of rpiB

 

High impact information on rpiB

  • D-Allose catabolism of Escherichia coli: involvement of alsI and regulation of als regulon expression by allose and ribose [2].
  • Genes involved in allose utilization of Escherichia coli K-12 are organized in at least two operons, alsRBACE and alsI, located next to each other on the chromosome but divergently transcribed [2].
  • Mutants defective in alsI (allose 6-phosphate isomerase gene) and alsE (allulose 6-phosphate epimerase gene) were Als(-) [2].
  • Escherichia coli strains defective in the rpiA gene, encoding ribose phosphate isomerase A, are ribose auxotrophs, despite the presence of the wild-type rpiB gene, which encodes ribose phosphate isomerase B. Ribose prototrophs of an rpiA genetic background were isolated by two different approaches [1].
  • Secondly, ribose prototrophs resulted from the cloning of the rpiB gene on a multicopy plasmid [1].
 

Biological context of rpiB

  • Consistent with this map position, the cloned DNA fragment contained two divergent open reading frames of 149 and 296 codons, encoding ribose phosphate isomerase B (molecular mass, 16,063 Da) and a negative regulator of rpiB gene expression, RpiR (molecular mass, 32,341 Da), respectively [1].
 

Other interactions of rpiB

  • The 5' ends of rpiB- and rpiR-specified transcripts were located by primer extension analysis [1].

References

 
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