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Gene Review

phnD  -  phosphonate ABC transporter periplasmic...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4098, JW4066, psiD
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Disease relevance of phnD


High impact information on phnD

  • Here we report the characterization of the phosphonate-binding properties of the phnD protein product [2].
  • The Escherichia coli phn (psiD) locus consists of a large gene cluster encoding proteins necessary for the use of phosphonates (Pn) as a sole phosphorus source [3].
  • The Escherichia coli phn (psiD) locus encodes genes for phosphonate (Pn) utilization, for phn (psiD) mutations abolish the ability to use as a sole P source a Pn with a substituted C-2 or unsubstituted hydrocarbon group such as 2-aminoethylphosphonate (AEPn) or methylphosphonate (MPn), respectively [4].
  • Also, Mu d1s in the phoA and phn (psiD) loci of the phosphate regulon showed regional specificities for the insertion sites despite the randomness of Mu d1 insertions into the genome as a whole [5].
  • The phn(EcoB) DNA hybridized to overlapping lambda clones in the E. coli K-12 gene library (Y. Kohara, K. Akiyama, and K. Isono, Cell 50:495-508, 1987) which contain the 93-min region, thus showing that the phn (psiD) locus was itself cloned and verifying our genetic data on its map location [4].

Chemical compound and disease context of phnD


Biological context of phnD

  • The phn (psiD) gene cluster is induced during Pi limitation and is required for the use of phosphonates (Pn) as a phosphorus (P) source [6].

Associations of phnD with chemical compounds

  • Since psiD::lacZ(Mu d1) mutants cannot metabolize methylphosphonic acid, psiD may be the structural gene(s) for C-P lyase [7].

Analytical, diagnostic and therapeutic context of phnD


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