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Gene Review

pepA  -  multifunctional aminopeptidase A: a...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4253, JW4217, carP, xerB
 
 
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Disease relevance of pepA

 

High impact information on pepA

  • This plasmid stabilizing recombination system requires the presence in cis of the ColE1 cer region, plus at least two trans-acting factors encoded by the xerA and xerB genes of Escherichia coli [1].
  • carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers [3].
  • Mobility-shift and DNase I footprinting experiments have revealed a specific binding of purified CarP (PepA) to two sites in each one of the control regions of the E. coli and Salmonella typhimurium carAB operons and to a single site in the carP (pepA) control region [3].
  • The carP (pepA) control region was sequenced and transcription shown to be initiated at three promoters, the most upstream one of which was shown to be subject to negative autoregulation [3].
  • The DNA sequence of a 2.1 kb fragment containing pepA was determined [4].
 

Biological context of pepA

  • Mutants of L. lactis in which the pepA gene was inactivated grew to normal cell densities in milk but exhibited a reduced growth rate during the exponential phase [4].
 

Associations of pepA with chemical compounds

  • We have isolated a new type of constitutive mutation (carP) that specifically affects the control of the pyrimidine-sensitive promoter but does not appear to influence other genes of the pyrimidine pathway [5].

References

  1. xerB, an Escherichia coli gene required for plasmid ColE1 site-specific recombination, is identical to pepA, encoding aminopeptidase A, a protein with substantial similarity to bovine lens leucine aminopeptidase. Stirling, C.J., Colloms, S.D., Collins, J.F., Szatmari, G., Sherratt, D.J. EMBO J. (1989) [Pubmed]
  2. Molecular cloning and DNA sequence analysis of pepL, a leucyl aminopeptidase gene from Lactobacillus delbrueckii subsp. lactis DSM7290. Klein, J.R., Dick, A., Schick, J., Matern, H.T., Henrich, B., Plapp, R. Eur. J. Biochem. (1995) [Pubmed]
  3. carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers. Charlier, D., Hassanzadeh, G., Kholti, A., Gigot, D., Piérard, A., Glansdorff, N. J. Mol. Biol. (1995) [Pubmed]
  4. A non-essential glutamyl aminopeptidase is required for optimal growth of Lactococcus lactis MG1363 in milk. l'Anson, K.J., Movahedi, S., Griffin, H.G., Gasson, M.J., Mulholland, F. Microbiology (Reading, Engl.) (1995) [Pubmed]
  5. carP, a novel gene regulating the transcription of the carbamoylphosphate synthetase operon of Escherichia coli. Roovers, M., Charlier, D., Feller, A., Gigot, D., Holemans, F., Lissens, W., Piérard, A., Glansdorff, N. J. Mol. Biol. (1988) [Pubmed]
 
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