Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

serB - 3-phosphoserine phosphatase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4380, JW4351

Neuwald, A.F. et al., Neuwald, A.F. et al., Barcus, V.A. et al., Neuwald, A.F. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of serB

We have determined the sequence of a DNA fragment containing the Escherichia coli serB gene [1].
In enteric bacteria three discrete families of type I restriction and modification systems (IA, IB and ID) are encoded by alleles of the serB-linked hsd locus [2].

High impact information on serB

The -10 and -35 regions of the serB promoter lack homology to the consensus sequences [1].
DNA sequence and characterization of the Escherichia coli serB gene [1].
Frameshift mutations were constructed at three different sites within the serB gene [1].
Analyses using sms'-lacZ fusions cloned downstream from wild-type and mutant serB promoters showed that sms is cotranscribed with serB [3].
We describe a gene, designated sms, which is downstream from the serine biosynthetic gene serB in Escherichia coli but does not appear to be involved in amino acid (aa) biosynthesis [3].

Biological context of serB

Mutational analysis of the Escherichia coli serB promoter region reveals transcriptional linkage to a downstream gene [3].

Other interactions of serB

The smp gene, whose promoter divergently overlaps with the Escherichia coli serB promoter, encodes a 24-kDa membrane protein of unknown function [4].

References

DNA sequence and characterization of the Escherichia coli serB gene. Neuwald, A.F., Stauffer, G.V. Nucleic Acids Res. (1985) [Pubmed]
The diversity of alleles at the hsd locus in natural populations of Escherichia coli. Barcus, V.A., Titheradge, A.J., Murray, N.E. Genetics (1995) [Pubmed]
Mutational analysis of the Escherichia coli serB promoter region reveals transcriptional linkage to a downstream gene. Neuwald, A.F., Berg, D.E., Stauffer, G.V. Gene (1992) [Pubmed]
An Escherichia coli membrane protein with a unique signal sequence. Neuwald, A.F., Stauffer, G.V. Gene (1989) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.