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Gene Review: 

norV  -  anaerobic nitric oxide reductase...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2705, JW2680, flrd, ygaI, ygaJ, ...
 
 
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Disease relevance of norV

  • Exposure of E. coli to sub-micromolar NO levels under anaerobic conditions rapidly induced transcription of the NO reductase (NOR) structural genes, norV and norW, as monitored by lac gene fusions [1].
 

High impact information on norV

  • In aerobic cultures, only 17 genes were significantly up-regulated, including genes known to be involved in NO tolerance, particularly hmp (encoding the NO-consuming flavohemoglobin Hmp) and norV (encoding flavorubredoxin) [2].
  • However, elevated NOR activity inhibited NO dioxygenase induction, and, in the presence of dioxygen, NO dioxygenase inhibited norV induction by NO [1].
  • Three binding sites for NorR and two integration host factor binding sites were identified in the norR-norV intergenic region [3].
 

Associations of norV with chemical compounds

  • Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR [4].

References

  1. Regulation of the nitric oxide reduction operon (norRVW) in Escherichia coli. Role of NorR and sigma54 in the nitric oxide stress response. Gardner, A.M., Gessner, C.R., Gardner, P.R. J. Biol. Chem. (2003) [Pubmed]
  2. Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesis. Flatley, J., Barrett, J., Pullan, S.T., Hughes, M.N., Green, J., Poole, R.K. J. Biol. Chem. (2005) [Pubmed]
  3. DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria. Tucker, N.P., D'Autréaux, B., Studholme, D.J., Spiro, S., Dixon, R. J. Bacteriol. (2004) [Pubmed]
  4. The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species. Hutchings, M.I., Mandhana, N., Spiro, S. J. Bacteriol. (2002) [Pubmed]
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