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Gene Review

drgA  -  DrgA gene product

Synechocystis sp. PCC 6803

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Disease relevance of drgA

  • Resistance to nitrophenolic herbicides and metronidazole in the cyanobacterium Synechocystis sp. PCC 6803 as a result of the inactivation of a nitroreductase-like protein encoded by drgA gene [1].
  • The results suggest that NQR, encoded by the drgA gene, might participate in the regulation of cytoplasmic NADPH oxidation, supplying NADP+ for glucose oxidation in the pentose phosphate cycle of cyanobacteria [2].
 

High impact information on drgA

  • The mutation in the drgA gene did not impair the ability of Synechocystis sp. PCC 6803 cells to oxidize glucose under heterotrophic conditions and did not impair the NDH-1-dependent, rotenone-inhibited electron transfer from NADPH to P700+ in thylakoid membranes of the cyanobacterium [2].
  • Insertion mutant Ins2 of the cyanobacterium Synechocystis sp. PCC 6803, lacking NAD(P)H:quinone oxidoreductase (NQR) encoded by drgA gene, was characterized by higher sensitivity to quinone-type inhibitors (menadione and plumbagin) than wild type (WT) cells [3].

References

  1. Resistance to nitrophenolic herbicides and metronidazole in the cyanobacterium Synechocystis sp. PCC 6803 as a result of the inactivation of a nitroreductase-like protein encoded by drgA gene. Elanskaya, I.V., Chesnavichene, E.A., Vernotte, C., Astier, C. FEBS Lett. (1998) [Pubmed]
  2. Reduction of photosystem I reaction center in DrgA mutant of the cyanobacterium Synechocystis sp. PCC 6803 lacking soluble NAD(P)H:quinone oxidoreductase. Elanskaya, I.V., Timofeev, K.N., Grivennikova, V.G., Kuznetsova, G.V., Davletshina, L.N., Lukashev, E.P., Yaminsky, F.V. Biochemistry Mosc. (2004) [Pubmed]
  3. Role of NAD(P)H:quinone oxidoreductase encoded by drgA gene in reduction of exogenous quinones in cyanobacterium Synechocystis sp. PCC 6803 cells. Elanskaya, I.V., Grivennikova, V.G., Groshev, V.V., Kuznetsova, G.V., Semina, M.E., Timofeev, K.N. Biochemistry Mosc. (2004) [Pubmed]
 
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