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Gene Review:

citA - sensor-type protein

Escherichia coli O157:H7 str. EDL933

Jin, S. et al., Bott, M. et al., Achenbach, L.A. et al., Hall, B.G.

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Disease relevance of citA

The citA gene was cloned by genetic complementation of an Escherichia coli citrate synthase mutant strain (W620) and was in a monocistronic transcriptional unit [1].
Two distinct Bacillus subtilis genes (citA and citZ) were found to encode citrate synthase isozymes that catalyze the first step of the Krebs cycle [1].

High impact information on citA

In a citA null mutant which expressed citB constitutively at high levels, none of these signals was required for the formation of the citrate fermentation enzymes [2].
Nucleotide sequence analysis of this region revealed the presence of two adjacent genes, citA and citB [2].
An open reading frame located 50 bases downstream from the fur stop codon appears to be a truncated citA gene that, if functional, would encode only the carboxy terminus of a citrate utilization protein [3].
Citrate utilization arose as the consequence of two mutations in genes citA and citB, which are linked to the gal operon [4].

References

Identification of two distinct Bacillus subtilis citrate synthase genes. Jin, S., Sonenshein, A.L. J. Bacteriol. (1994) [Pubmed]
Regulation of anaerobic citrate metabolism in Klebsiella pneumoniae. Bott, M., Meyer, M., Dimroth, P. Mol. Microbiol. (1995) [Pubmed]
The fur gene from Klebsiella pneumoniae: characterization, genomic organization and phylogenetic analysis. Achenbach, L.A., Yang, W. Gene (1997) [Pubmed]
Chromosomal mutation for citrate utilization by Escherichia coli K-12. Hall, B.G. J. Bacteriol. (1982) [Pubmed]

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