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Gene Review

cbpA  -  curved DNA-binding protein CbpA

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of cbpA

 

High impact information on cbpA

  • The cbpA gene consists of 5544 base pairs and encodes a protein containing 1848 amino acids with a molecular mass of 189,036 Da [1].
  • The C-terminal region of ExgS contains a duplicated sequence (DS), each sequence consisting of 22 amino acids. exgS, located 67 bp downstream of cbpA in the chromosome, is immediately upstream of a gene encoding a family 9 type endoglucanase that we have designated as EngH [2].
  • Sequence analyses of the S. typhimurium scs genes and adjacent DNAs revealed that the scs locus is flanked by genes with high homology to the cbpA (predicted curved DNA-binding protein) and agp (acid glucose phosphatase) genes of E. coli located at 22.90 min (1,062.07 kb) and 22.95 min (1,064.8 kb) of the E. coli chromosome, respectively [3].
  • Expression of cbpA (biphenyl dioxygenase, 6.2 U/mg of protein) and cbpC (3-phenylcatechol dioxygenase, 611.00 U/mg of protein) genes was also found in E. coli containing the hybrid plasmid pAW540 [4].
  • These results demonstrate that the cloned DNA fragments contain genes encoding for chlorobiphenyl dioxygenase (cbpA), dihydrodiol dehydrogenase (cbpB), 4'-chloro-3-phenylcatechol dioxygenase (cbpC), a meta-cleavage compound (a chloro derivative of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate) hydrolase (cbpD), and a new dechlorinating activity (dcpE) [5].
 

Biological context of cbpA

References

  1. Primary sequence analysis of Clostridium cellulovorans cellulose binding protein A. Shoseyov, O., Takagi, M., Goldstein, M.A., Doi, R.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Properties of exgS, a gene for a major subunit of the Clostridium cellulovorans cellulosome. Liu, C.C., Doi, R.H. Gene (1998) [Pubmed]
  3. A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli. Gupta, S.D., Wu, H.C., Rick, P.D. J. Bacteriol. (1997) [Pubmed]
  4. Expression, localization, and functional analysis of polychlorinated biphenyl degradation genes cbpABCD of Pseudomonas putida. Khan, A.A., Walia, S.K. Appl. Environ. Microbiol. (1991) [Pubmed]
  5. Cloning of bacterial genes specifying degradation of 4-chlorobiphenyl from Pseudomonas putida OU83. Khan, A., Walia, S. Appl. Environ. Microbiol. (1989) [Pubmed]
  6. Enhancement of acid tolerance in Zymomonas mobilis by a proton-buffering peptide. Baumler, D.J., Hung, K.F., Bose, J.L., Vykhodets, B.M., Cheng, C.M., Jeong, K.C., Kaspar, C.W. Appl. Biochem. Biotechnol. (2006) [Pubmed]
 
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