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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

soxS  -  DNA-binding transcriptional regulator SoxS

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of soxS

 

High impact information on soxS

  • Activated SoxR turns on transcription of a single gene, soxS, which encodes a transcriptional regulator that activates a regulon that includes dozens of oxidative stress response genes [2].
  • Deletion of soxS or rob alone was more detrimental than the removal of marA [1].
 

Biological context of soxS

  • Organisms lacking all three transcription factors (triple knockouts) were significantly less virulent than parental strains, and complementation studies demonstrated that the addition of marA, soxS and rob individually restored wild-type virulence in the triple-knockout strain [1].

References

  1. MarA, SoxS and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritis. Casaz, P., Garrity-Ryan, L.K., McKenney, D., Jackson, C., Levy, S.B., Tanaka, S.K., Alekshun, M.N. Microbiology (Reading, Engl.) (2006) [Pubmed]
  2. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Palma, M., Zurita, J., Ferreras, J.A., Worgall, S., Larone, D.H., Shi, L., Campagne, F., Quadri, L.E. Infect. Immun. (2005) [Pubmed]
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