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Gene Review

glgP  -  glycogen phosphorylase

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of glgP

  • Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli [1].
  • Molecular mechanisms of McArdle's disease (muscle glycogen phosphorylase deficiency). RNA and DNA analysis [2].
  • We identified a novel mutation in the glycogen phosphorylase gene (PGYL) in a Chinese patient with glycogen storage disease (GSD) type VI [3].
  • These decreased [Ca2+]c levels were associated with changes of glycogen phosphorylase activity in a manner suggesting a cause and effect relationship; e.g., acute ET treatment resulted in greater than 80% depression of phosphorylase a activity, whereas sepsis induced a 58% decrease in the activity of this enzyme [4].
 

High impact information on glgP

 

Chemical compound and disease context of glgP

 

Anatomical context of glgP

  • The recombinant protein, after purification by a single affinity chromatography step, displayed phosphatase activity towards a number of substrates, including myelin basic protein, histone 2A and casein, but was ineffective in dephosphorylating glycogen phosphorylase [10].

References

  1. Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli. Alonso-Casajús, N., Dauvillée, D., Viale, A.M., Muñoz, F.J., Baroja-Fernández, E., Morán-Zorzano, M.T., Eydallin, G., Ball, S., Pozueta-Romero, J. J. Bacteriol. (2006) [Pubmed]
  2. Molecular mechanisms of McArdle's disease (muscle glycogen phosphorylase deficiency). RNA and DNA analysis. Gautron, S., Daegelen, D., Mennecier, F., Dubocq, D., Kahn, A., Dreyfus, J.C. J. Clin. Invest. (1987) [Pubmed]
  3. A novel mutation (G233D) in the glycogen phosphorylase gene in a patient with hepatic glycogen storage disease and residual enzyme activity. Tang, N.L., Hui, J., Young, E., Worthington, V., To, K.F., Cheung, K.L., Li, C.K., Fok, T.F. Mol. Genet. Metab. (2003) [Pubmed]
  4. Rat liver free cytosolic Ca2+ and glycogen phosphorylase in endotoxicosis and sepsis. Deaciuc, I.V., Spitzer, J.A. Am. J. Physiol. (1986) [Pubmed]
  5. High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPr. Seok, Y.J., Sondej, M., Badawi, P., Lewis, M.S., Briggs, M.C., Jaffe, H., Peterkofsky, A. J. Biol. Chem. (1997) [Pubmed]
  6. L-serine binds to arginine-148 of the beta 2 subunit of Escherichia coli tryptophan synthase. Tanizawa, K., Miles, E.W. Biochemistry (1983) [Pubmed]
  7. Frequency-dependent phosphorus-31 nuclear magnetic resonance studies of the phosphohistidine residue to succinyl-CoA synthetase and the phosphoserine residue of glycogen phosphorylase a. Vogel, H.J., Bridger, W.A., Sykes, B.D. Biochemistry (1982) [Pubmed]
  8. Gene organization and transcription analysis of the Agrobacterium tumefaciens glycogen (glg) operon: two transcripts for the single phosphoglucomutase gene. Ugalde, J.E., Lepek, V., Uttaro, A., Estrella, J., Iglesias, A., Ugalde, R.A. J. Bacteriol. (1998) [Pubmed]
  9. Regulation of E. coli glycogen phosphorylase activity by HPr. Seok, Y.J., Koo, B.M., Sondej, M., Peterkofsky, A. J. Mol. Microbiol. Biotechnol. (2001) [Pubmed]
  10. Biochemical characterization of recombinant yeast PPZ1, a protein phosphatase involved in salt tolerance. Posas, F., Bollen, M., Stalmans, W., Ariño, J. FEBS Lett. (1995) [Pubmed]
 
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