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Gene Review

FAM53B  -  family with sequence similarity 53, member B

Homo sapiens

Synonyms: KIAA0140, Protein FAM53B, bA12J10.2, smp
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High impact information on FAM53B

  • We showed that FAM53B bound 14-3-3 chaperones, as well as SKIIP proteins, adaptor proteins connecting DNA-binding proteins to modulators of transcription. smp inactivation with morpholinos led to delayed epiboly and reduced embryonic size [1].
  • Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes controlling cell proliferation [1].
  • Using an in situ screen on a cortical structure of the medaka fish brain, we identified the simplet gene (smp), which is homologous to the human FAM53B gene. smp was expressed in actively proliferating cells of the CNS throughout embryogenesis [1].


  1. Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes controlling cell proliferation. Thermes, V., Candal, E., Alunni, A., Serin, G., Bourrat, F., Joly, J.S. Development (2006) [Pubmed]
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