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Gene Review

TRAM2  -  translocation associated membrane protein 2

Homo sapiens

Synonyms: KIAA0057, Translocating chain-associated membrane protein 2
 
 
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Disease relevance of TRAM2

  • Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene [1].
 

High impact information on TRAM2

  • TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis [2].
  • Here we describe a role for the protein TRAM2 in collagen type I expression in hepatic stellate cells (HSCs) and fibroblasts [2].
 

Analytical, diagnostic and therapeutic context of TRAM2

References

  1. Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. Onuchic, L.F., Mrug, M., Lakings, A.L., Muecher, G., Becker, J., Zerres, K., Avner, E.D., Dixit, M., Somlo, S., Germino, G.G., Guay-Woodford, L.M. Mamm. Genome (1999) [Pubmed]
  2. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Stefanovic, B., Stefanovic, L., Schnabl, B., Bataller, R., Brenner, D.A. Mol. Cell. Biol. (2004) [Pubmed]
 
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