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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lmo1421  -  glycine/betaine ABC transporter ATP...

Listeria monocytogenes EGD-e

 
 
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Disease relevance of lmo1421

  • Sigma(B)-dependent expression patterns of compatible solute transporter genes opuCA and lmo1421 and the conjugated bile salt hydrolase gene bsh in Listeria monocytogenes [1].
 

High impact information on lmo1421

  • Additionally, despite being transcriptionally up-regulated upon cold shock, a putative fourth osmolyte transporter, OpuB (identified by bioinformatic analysis and encoded by lmo1421 and lmo1422), showed no significant contribution to listerial chill tolerance [2].
  • The osmotic induction of opuCA and lmo1421 was found to be strongly sigma(B) dependent [3].
  • Reverse transcriptase PCR experiments confirmed these data and indicated that the transcription of all three known compatible solute uptake systems (opuC, betL, and gbu), as well as a gene that is predicted to encode a compatible solute transporter subunit (lmo1421) is induced in response to elevated osmolarity [3].
 

Analytical, diagnostic and therapeutic context of lmo1421

  • RT-PCR demonstrated that opuCA, lmo1421 and bsh transcript levels are reduced in stationary-phase L. monocytogenes deltasigB cells relative to levels present in wild-type cells [1].

References

  1. Sigma(B)-dependent expression patterns of compatible solute transporter genes opuCA and lmo1421 and the conjugated bile salt hydrolase gene bsh in Listeria monocytogenes. Sue, D., Boor, K.J., Wiedmann, M. Microbiology (Reading, Engl.) (2003) [Pubmed]
  2. Molecular and physiological analysis of the role of osmolyte transporters BetL, Gbu, and OpuC in growth of Listeria monocytogenes at low temperatures. Wemekamp-Kamphuis, H.H., Sleator, R.D., Wouters, J.A., Hill, C., Abee, T. Appl. Environ. Microbiol. (2004) [Pubmed]
  3. Role of sigmaB in regulating the compatible solute uptake systems of Listeria monocytogenes: osmotic induction of opuC is sigmaB dependent. Fraser, K.R., Sue, D., Wiedmann, M., Boor, K., O'Byrne, C.P. Appl. Environ. Microbiol. (2003) [Pubmed]
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