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Gene Review: 

Kcnb2  -  potassium voltage gated channel, Shab...

Mus musculus

Synonyms: 9630047L19Rik, BB130875, Kv2.2, Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv2.2
 
 
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High impact information on Kcnb2

  • The increasing number of modulatory subunits for Kv2.1 and Kv2.2 provides an amazingly new capacity of functional diversity [1].
  • A chaperone-like effect of mKvbeta4 seems to permit the integration of a larger number of Kv2.2 channels at the plasma membrane [2].
  • Instead, mKvbeta4 associates to Kv2.2 (CDRK), a Shab K+ channel, to specifically enhance (a factor of up to 6) its expression level without changing its elementary conductance or kinetics [2].

References

  1. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas, M., Duprat, F., Heurteaux, C., Hugnot, J.P., Lazdunski, M. J. Biol. Chem. (1997) [Pubmed]
  2. A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. Fink, M., Duprat, F., Lesage, F., Heurteaux, C., Romey, G., Barhanin, J., Lazdunski, M. J. Biol. Chem. (1996) [Pubmed]
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