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Dpyd  -  dihydropyrimidine dehydrogenase

Mus musculus

Synonyms: AI315208, DHPDHase, DPD, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, ...
 
 
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Disease relevance of Dpyd

  • In vivo experiments were performed on breast cancer xenografts to examine whether the combination therapy with S-1, an oral dihydrouracil dehydrogenase (DPD) inhibitory fluoropyrimidine, plus docetaxel functions as an additive/synergistic modulator in tumor growth [1].
  • Highly purified tetanus toxin at 2.5 x 10(5) 50% lethal doses per ml lost all toxicity in 40 mM PTL or 150 mM DPD but was not detectably affected by 100 mM HQL (the highest concentration possible) [2].
  • The DPD-overexpressing cells were obtained by transfection of human DPD cDNA into HCT116 human colorectal cancer cells [3].
  • No acute toxicity was observed after an intraperitoneal challenge of DPD in BALB/c-nude mice weekly [4].
  • In this study, we examined the in vitro and in vivo effects of DPD on human colon cancer cells [4].
 

High impact information on Dpyd

 

Chemical compound and disease context of Dpyd

 

Biological context of Dpyd

 

Anatomical context of Dpyd

 

Associations of Dpyd with chemical compounds

 

Other interactions of Dpyd

  • Individual liver DPD expression varied from 761 to 3481 units (DPD/beta actin ratio); the mean was lowest at 3 HALO (1406+/-112) and highest at 15 HALO (2067+/-214) [10].
 

Analytical, diagnostic and therapeutic context of Dpyd

References

  1. Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice. Suto, A., Kubota, T., Fukushima, M., Ikeda, T., Takeshita, T., Ohmiya, H., Kitajima, M. Oncol. Rep. (2006) [Pubmed]
  2. Inactivation of botulinum and tetanus toxins by chelators. Bhattacharyya, S.D., Sugiyama, H. Infect. Immun. (1989) [Pubmed]
  3. Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Endo, M., Miwa, M., Eda, H., Ura, M., Tanimura, H., Ishikawa, T., Miyazaki-Nose, T., Hattori, K., Shimma, N., Yamada-Okabe, H., Ishitsuka, H. Int. J. Cancer (2003) [Pubmed]
  4. Study of in vitro and in vivo effects of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl]diamantane (DPD), a novel cytostatic and differentiation inducing agent, on human colon cancer cells. Wang, J.J., Chang, Y.F., Chern, Y.T., Chi, C.W. Br. J. Cancer (2003) [Pubmed]
  5. Pyrimidine base degradation in cultured murine C-1300 neuroblastoma cells and in situ tumors. Tuchman, M., O'Dea, R.F., Ramnaraine, M.L., Mirkin, B.L. J. Clin. Invest. (1988) [Pubmed]
  6. 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. Baccanari, D.P., Davis, S.T., Knick, V.C., Spector, T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy. Adams, E.R., Leffert, J.J., Craig, D.J., Spector, T., Pizzorno, G. Cancer Res. (1999) [Pubmed]
  8. Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34+-enriched peripheral blood progenitor cells. Takebe, N., Zhao, S.C., Ural, A.U., Johnson, M.R., Banerjee, D., Diasio, R.B., Bertino, J.R. Cancer Gene Ther. (2001) [Pubmed]
  9. CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNA in mouse liver. Shimizu, M., Tamura, T., Yamada, Y., Akiyama, Y., Saijo, N., Nishio, K. Jpn. J. Cancer Res. (2001) [Pubmed]
  10. Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression. Porsin, B., Formento, J.L., Filipski, E., Etienne, M.C., Francoual, M., Renée, N., Magné, N., Lévi, F., Milano, G. Eur. J. Cancer (2003) [Pubmed]
  11. Regulation of dihydropyrimidine dehydrogenase gene expression in regenerating mouse liver. Yamada, H., Fukushima, M., Koizumi, K., Katakura, H., Nakanishi, H., Teshima, S., Kamiyama, Y., Ikenaka, K. Int. J. Oncol. (2003) [Pubmed]
  12. 5-Ethynyluracil (776C85): inactivation of dihydropyrimidine dehydrogenase in vivo. Spector, T., Harrington, J.A., Porter, D.J. Biochem. Pharmacol. (1993) [Pubmed]
  13. Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice. Filipski, E., King, V.M., Etienne, M.C., Li, X., Claustrat, B., Granda, T.G., Milano, G., Hastings, M.H., Lévi, F. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  14. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Ishikawa, T., Sekiguchi, F., Fukase, Y., Sawada, N., Ishitsuka, H. Cancer Res. (1998) [Pubmed]
 
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