Disease relevance of Diarrhea

• From their files the thirty-day post-disaster incidence of acute diarrheas (AD), respiratory tract infectious diseases (ARD), and malaria were estimated and compared with off-crisis data [1].

High impact information on Diarrhea

• Comparison of sucrose and glucose in the oral electrolyte therapy of cholera and other severe diarrheas [2].
• CFTR inhibition may thus reduce fluid secretion in infectious secretory diarrheas [3].
• Mechanisms of Bacterial diarrheas [4].
• Somatostatin analogues such as octreotide have approximately 50% efficacy in reduction of the moderate secretory diarrheas such as those present in AIDS [5].
• Mild, nondysenteric diarrheas can be safely and reasonably effectively treated either with loperamide or with bismuth subsalicylate compounds [5].

Chemical compound and disease context of Diarrhea

• Stool chloride provides information relevant to congenital and acquired diarrheas [6].

Anatomical context of Diarrhea

• Studies of protective immune mechanisms have emphasized the importance of secretory IgA antibodies and mucosal memory for protection against noninvasive, enterotoxigenic infections such as cholera and ETEC diarrhea and also drawn attention to the possible protective role of IFN-gamma production by intestinal T cells in these secretory diarrheas [7].

Gene context of Diarrhea

• Somatostatin analog, SMS 201-995, effectively inhibits the release of hormones from gastrointestinal endocrine tumors and reduces hormonally mediated diarrheas [8].

References