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MeSH Review

Ventricular Function

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Disease relevance of Ventricular Function


High impact information on Ventricular Function


Chemical compound and disease context of Ventricular Function


Biological context of Ventricular Function


Anatomical context of Ventricular Function


Associations of Ventricular Function with chemical compounds


Gene context of Ventricular Function

  • CT-1 may be of central importance to the pathogenesis of ventricular remodelling in patients with acute myocardial infarction (AMI) and therefore have clinical value in the identification of patients with impaired ventricular function [30].
  • In the diagnosis of CHF, plasma levels of ET-1 appear to be a less powerful discriminator between patients with mild disease and control subjects with normal ventricular function on multivariate analyses, compared to brain natriuretic peptide (BNP), or its N-terminal fragment [31].
  • The current study examines whether qualitative changes or altered distribution of gap junctional connexin43 (Cx43) are related to global ventricular function and ventricular arrhythmia in DCM [32].
  • The alpha(1)-inhibitor prazosin decreased blood pressure in DS similar to spironolactone treatment, but did not normalize the plasma levels of endothelin-1 and NE, NE reuptake, or ventricular function [33].
  • This study was designed to evaluate the effects of intramyocardial administration of bFGF on myocardial blood flow, angiogenesis, and ventricular function in a canine acute infarction model [34].

Analytical, diagnostic and therapeutic context of Ventricular Function


  1. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure. Singh, S.N., Fletcher, R.D., Fisher, S.G., Singh, B.N., Lewis, H.D., Deedwania, P.C., Massie, B.M., Colling, C., Lazzeri, D. N. Engl. J. Med. (1995) [Pubmed]
  2. Intracellular calcium and ventricular function. Effects of nisoldipine on global ischemia in the isovolumic, coronary-perfused heart. Amende, I., Bentivegna, L.A., Zeind, A.J., Wenzlaff, P., Grossman, W., Morgan, J.P. J. Clin. Invest. (1992) [Pubmed]
  3. Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty. Afridi, I., Kleiman, N.S., Raizner, A.E., Zoghbi, W.A. Circulation (1995) [Pubmed]
  4. The mechanism of mannitol in reducing ischemic injury: hyperosmolarity or hydroxyl scavenger? Magovern, G.J., Bolling, S.F., Casale, A.S., Bulkley, B.H., Gardner, T.J. Circulation (1984) [Pubmed]
  5. Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. McCarthy, R.E., Boehmer, J.P., Hruban, R.H., Hutchins, G.M., Kasper, E.K., Hare, J.M., Baughman, K.L. N. Engl. J. Med. (2000) [Pubmed]
  6. Prevention of implantable-defibrillator shocks by treatment with sotalol. d,l-Sotalol Implantable Cardioverter-Defibrillator Study Group. Pacifico, A., Hohnloser, S.H., Williams, J.H., Tao, B., Saksena, S., Henry, P.D., Prystowsky, E.N. N. Engl. J. Med. (1999) [Pubmed]
  7. Arrhythmia susceptibility and myocardial composition in diabetes. Influence of physical conditioning. Bakth, S., Arena, J., Lee, W., Torres, R., Haider, B., Patel, B.C., Lyons, M.M., Regan, T.J. J. Clin. Invest. (1986) [Pubmed]
  8. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia. Anderson, L.J., Wonke, B., Prescott, E., Holden, S., Walker, J.M., Pennell, D.J. Lancet (2002) [Pubmed]
  9. Adjuvant xamoterol or metoprolol in patients with malignant ventricular arrhythmia resistant to amiodarone. Paul, V., Griffith, M., Ward, D.E., Camm, A.J. Lancet (1989) [Pubmed]
  10. Relationship of blood flow effects of adenosine during reperfusion to recovery of ventricular function after hypothermic ischemia in neonatal lambs. Nomura, F., Forbess, J.M., Hiramatsu, T., Mayer, J.E. Circulation (1997) [Pubmed]
  11. Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function. Hammerman, H., Kloner, R.A., Hale, S., Schoen, F.J., Braunwald, E. Circulation (1983) [Pubmed]
  12. Utility of history, physical examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure. Thomas, J.T., Kelly, R.F., Thomas, S.J., Stamos, T.D., Albasha, K., Parrillo, J.E., Calvin, J.E. Am. J. Med. (2002) [Pubmed]
  13. Acute effect of disopyramide on atrial fibrillation in the Wolff-Parkinson-White syndrome. Fujimura, O., Klein, G.J., Sharma, A.D., Yee, R., Szabo, T. J. Am. Coll. Cardiol. (1989) [Pubmed]
  14. Effect of pyruvate on regional ventricular function in normal and stunned myocardium. Mentzer, R.M., Van Wylen, D.G., Sodhi, J., Weiss, R.J., Lasley, R.D., Willis, J., Bünger, R., Habil, n.u.l.l., Flint, L.M. Ann. Surg. (1989) [Pubmed]
  15. Dobutamine increases cardiac output of the total artificial heart. Implications for vascular contribution of inotropic agents to augmented ventricular function. Binkley, P.F., Murray, K.D., Watson, K.M., Myerowitz, P.D., Leier, C.V. Circulation (1991) [Pubmed]
  16. Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange. Tani, M., Neely, J.R. Circ. Res. (1989) [Pubmed]
  17. Increased plasma endothelin-1 in the early hours of acute myocardial infarction. Stewart, D.J., Kubac, G., Costello, K.B., Cernacek, P. J. Am. Coll. Cardiol. (1991) [Pubmed]
  18. Involvement of hydrogen peroxide and hydroxyl radical in the 'oxygen paradox': reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase. Myers, C.L., Weiss, S.J., Kirsh, M.M., Shlafer, M. J. Mol. Cell. Cardiol. (1985) [Pubmed]
  19. Effect of vasopressin on postresuscitation ventricular function: unknown consequences of the recent Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Kern, K.B., Heidenreich, J.H., Higdon, T.A., Berg, R.A., Hilwig, R.W., Sanders, A.B., Anavy, N., Ewy, G.A. Crit. Care Med. (2004) [Pubmed]
  20. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Kaprielian, R.R., Gunning, M., Dupont, E., Sheppard, M.N., Rothery, S.M., Underwood, R., Pennell, D.J., Fox, K., Pepper, J., Poole-Wilson, P.A., Severs, N.J. Circulation (1998) [Pubmed]
  21. Myocardial infarction is coupled with activation of cyclins and cyclin-dependent kinases in myocytes. Reiss, K., Cheng, W., Giorando, A., De Luca, A., Li, B., Kajstura, J., Anversa, P. Exp. Cell Res. (1996) [Pubmed]
  22. Depressed cardiac myofilament function in human diabetes mellitus. Jweied, E.E., McKinney, R.D., Walker, L.A., Brodsky, I., Geha, A.S., Massad, M.G., Buttrick, P.M., de Tombe, P.P. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  23. Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy. Yoo, K.J., Li, R.K., Weisel, R.D., Mickle, D.A., Li, G., Yau, T.M. Ann. Thorac. Surg. (2000) [Pubmed]
  24. Partial Fontan: advantages of an adjustable interatrial communication. Laks, H., Pearl, J.M., Haas, G.S., Drinkwater, D.C., Milgalter, E., Jarmakani, J.M., Isabel-Jones, J., George, B.L., Williams, R.G. Ann. Thorac. Surg. (1991) [Pubmed]
  25. Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early afterload reducing therapy study. Solomon, S.D., Glynn, R.J., Greaves, S., Ajani, U., Rouleau, J.L., Menapace, F., Arnold, J.M., Hennekens, C., Pfeffer, M.A. Ann. Intern. Med. (2001) [Pubmed]
  26. Sodium and water excretion abnormalities in congestive heart failure. Determinant factors and clinical implications. Mettauer, B., Rouleau, J.L., Bichet, D., Juneau, C., Kortas, C., Barjon, J.N., de Champlain, J. Ann. Intern. Med. (1986) [Pubmed]
  27. Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size. Sinusas, A.J., Shi, Q., Vitols, P.J., Fetterman, R.C., Maniawski, P., Zaret, B.L., Wackers, F.J. Circulation (1993) [Pubmed]
  28. Coronary vasodilator reserve. Comparison of the effects of papaverine and adenosine on coronary flow, ventricular function, and myocardial metabolism. Christensen, C.W., Rosen, L.B., Gal, R.A., Haseeb, M., Lassar, T.A., Port, S.C. Circulation (1991) [Pubmed]
  29. Intravenous nitroglycerin in acute myocardial infarction. Flaherty, J.T., Reid, P.R., Kelly, D.T., Taylor, D.R., Weisfeldt, M.L., Pitt, B. Circulation (1975) [Pubmed]
  30. Prolonged stability of endogenous cardiotrophin-1 in whole blood. Downie, P.F., Talwar, S., Squire, I.B., Davies, J.E., Ng, L.L. Metab. Clin. Exp. (2001) [Pubmed]
  31. Diagnostic and therapeutic potential of the endothelin system in patients with chronic heart failure. Krum, H., Denver, R., Tzanidis, A., Martin, P. Heart failure reviews. (2001) [Pubmed]
  32. Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. Kitamura, H., Ohnishi, Y., Yoshida, A., Okajima, K., Azumi, H., Ishida, A., Galeano, E.J., Kubo, S., Hayashi, Y., Itoh, H., Yokoyama, M. J. Cardiovasc. Electrophysiol. (2002) [Pubmed]
  33. Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats. Buss, S.J., Backs, J., Kreusser, M.M., Hardt, S.E., Maser-Gluth, C., Katus, H.A., Haass, M. Endocrinology (2006) [Pubmed]
  34. Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor. Kawasuji, M., Nagamine, H., Ikeda, M., Sakakibara, N., Takemura, H., Fujii, S., Watanabe, Y. Ann. Thorac. Surg. (2000) [Pubmed]
  35. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon. Olafsson, B., Forman, M.B., Puett, D.W., Pou, A., Cates, C.U., Friesinger, G.C., Virmani, R. Circulation (1987) [Pubmed]
  36. Coronary revascularization rather than cardiac transplantation for chronic ischemic cardiomyopathy. Kron, I.L., Flanagan, T.L., Blackbourne, L.H., Schroeder, R.A., Nolan, S.P. Ann. Surg. (1989) [Pubmed]
  37. Superiority of "triple" drug therapy in heart failure: insights from the PROVED and RADIANCE trials. Prospective Randomized Study of Ventricular Function and Efficacy of Digoxin. Randomized Assessment of Digoxin and Inhibitors of Angiotensin-Converting Enzyme. Young, J.B., Gheorghiade, M., Uretsky, B.F., Patterson, J.H., Adams, K.F. J. Am. Coll. Cardiol. (1998) [Pubmed]
  38. Resolution of dilated cardiomyopathy after surgical ablation of ventricular tachycardia in a child. Fyfe, D.A., Gillette, P.C., Crawford, F.A., Kline, C.H. J. Am. Coll. Cardiol. (1987) [Pubmed]
  39. Simultaneous assessment of left ventricular wall motion and myocardial perfusion with technetium-99m-methoxy isobutyl isonitrile at stress and rest in patients with angina: comparison with thallium-201 SPECT. Villanueva-Meyer, J., Mena, I., Narahara, K.A. J. Nucl. Med. (1990) [Pubmed]
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