Disease relevance of Neonatal Abstinence Syndrome

• CONCLUSION: The neonatal abstinence syndrome was masked by congenital hypothyroidism until thyroxine treatment had normalised cellular metabolism [1].
• Unlike alcohol, neither the use of heroin nor methadone during pregnancy is associated with an increased risk of birth defects but both produce a neonatal abstinence syndrome that can persist for as long as 6 months; follow-up to preschool years suggests possible risk of attention deficit and problems of fine motor coordination [2].

High impact information on Neonatal Abstinence Syndrome

• A neonatal abstinence syndrome has occurred after maternal benzodiazepine consumption [3].
• Therefore, placental disposition of methadone might be an important contributor to the regulation of its concentration in the fetal circulation and consequently may affect the incidence and intensity of neonatal abstinence syndrome for women treated with the drug during pregnancy [4].
• Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants [5].
• This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth [6].
• PURPOSE: Length of hospital stay (LOS) of infants treated for neonatal abstinence syndrome (NAS) with methadone was compared to LOS of those treated with an oral morphine preparation (OMP, neonatal morphine solution, or deodorized tincture of opium) [7].

Chemical compound and disease context of Neonatal Abstinence Syndrome

• Neonatal abstinence syndrome was of longest duration in the methadone group [8].
• A randomised controlled trial of morphine versus phenobarbitone for neonatal abstinence syndrome [9].
• Neonatal withdrawal syndrome associated with hydroxyzine hydrochloride [10].
• Neonatal withdrawal syndrome in infants exposed to cocaine and methadone [11].
• OBJECTIVE: To determine the neonatal outcome in the form of use of morphine and triclofos to treat the neonatal abstinence syndrome following maternal opiate use in late pregnancy [12].

Biological context of Neonatal Abstinence Syndrome

• We report two infants who appeared to develop neonatal abstinence syndrome, after abrupt discontinuation of breast-feeding by women receiving 70 mg and 130 mg of methadone [13].

References