Disease relevance of Intervertebral Disk Chemolysis

• Chemonucleolysis. A preliminary report on a double blind study comparing chemonucleolysis and intradiscal administration of hydrocortisone in the treatment of backache and sciatica [1].

High impact information on Intervertebral Disk Chemolysis

• The effect of chemonucleolysis on serum keratan sulfate levels in humans [2].
• Enzymic analysis of urinary glycosaminoglycan after chemonucleolysis suggested that the increase in levels was largely due to an increase in the amounts of chondroitin sulphate present, probably resulting from proteoglycan breakdown in the intervertebral disc [3].
• STUDY DESIGN: A 5-year clinical follow-up assessment of a prospective randomized study of chemonucleolysis using chymopapain (4000 IU) or collagenase (400 ABC units) was performed [4].
• OBJECTIVE: To evaluate the effects of cathepsin L on intervertebral discs as an agent for chemonucleolysis [5].
• CONCLUSIONS: Cathepsin L seems to be an effective agent for chemonucleolysis [5].

Associations of Intervertebral Disk Chemolysis with chemical compounds

• The results of short and long term follow up demonstrate that inhibition of chymopapain by iotrolan or iopamidol is not to be expected and therefore diskography prior to chemonucleolysis can be performed without danger of enzyme inactivation [6].
• Although not statistically significant, the data suggest that chemonucleolysis was superior to intra-discal hydrocortisone in this series [7].
• The treatments assessed included chemonucleolysis, surgical discectomy, and epidural steroid injection [8].
• At the dose equivalent to that of chymopapain used in human chemonucleolysis, two human serine proteinases, cathepsin G and chymotrypsin, were as effective as chymopapain in removing up to 80% of the glycosaminoglycan from the disc [9].
• Chemonucleolysis of lumbar disc herniation with ethanol [10].

Gene context of Intervertebral Disk Chemolysis

• Experimental chemonucleolysis with chondroitinase ABC in monkeys [11].
• Chemonucleolysis failures treated by PLIF [12].
• Preoperative sera obtained from 11,658 chemonucleolysis candidates were tested, of which 0.94% (110/11,658) were found to be positive [13].
• The lateral approach for chemonucleolysis was developed to avoid dural puncture, which occurs with midline and posterolateral approaches [14].

Analytical, diagnostic and therapeutic context of Intervertebral Disk Chemolysis

• The results of this study show that measurements of blood levels of keratan sulfate could prove useful in monitoring effective degradation of disc proteoglycans in chemonucleolysis in man and help discriminate between ineffective enzyme placement, and alternative mechanisms of treatment failure [15].
• The neuroradiologic changes after chemonucleolysis were studied in animal experiments conducted to establish whether there is any interaction between chymopapain and the contrast medium iotrolan [16].

References