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MeSH Review


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Disease relevance of Ameloblastoma


High impact information on Ameloblastoma


Chemical compound and disease context of Ameloblastoma


Biological context of Ameloblastoma


Anatomical context of Ameloblastoma


Gene context of Ameloblastoma

  • Human ameloblastomas express AMBN transcripts that contain some mutations [21].
  • In ameloblastomas, expression of p53, MDM2, and p14(ARF) was significantly higher in plexiform cases than in follicular cases [16].
  • MVD tended to depend on VEGF expression levels in both benign and malignant ameloblastomas [22].
  • In ameloblastomas, these SHH signaling molecules were expressed more intensely in peripheral columnar or cuboidal cells than in central polyhedral cells; keratinizing cells and granular cells showed no or little reactivity [23].
  • Tumor cells in plexiform ameloblastomas showed slightly higher reactivity for PTHrP and ODF/RANKL than tumor cells in follicular ameloblastomas [24].

Analytical, diagnostic and therapeutic context of Ameloblastoma


  1. Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Sekine, S., Sato, S., Takata, T., Fukuda, Y., Ishida, T., Kishino, M., Shibata, T., Kanai, Y., Hirohashi, S. Am. J. Pathol. (2003) [Pubmed]
  2. Malignant ameloblastoma with pulmonary metastasis and hypercalcemia. Report of an autopsy case and review of the literature. Inoue, N., Shimojyo, M., Iwai, H., Ohtsuki, H., Yasumizu, R., Shintaku, M., Taniguchi, N., Inada, M., Arika, T., Morita, S. Am. J. Clin. Pathol. (1988) [Pubmed]
  3. Unicystic ameloblastoma: a clinicopathologic study of 33 Chinese patients. Li, T.J., Wu, Y.T., Yu, S.F., Yu, G.Y. Am. J. Surg. Pathol. (2000) [Pubmed]
  4. Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin. Grünwald, V., Le Blanc, S., Karstens, J.H., Weihkopf, T., Kuske, M., Ganser, A., Schöffski, P. Ann. Oncol. (2001) [Pubmed]
  5. Immunohistochemical detection and distribution of enamelysin (MMP-20) in human odontogenic tumors. Takata, T., Zhao, M., Uchida, T., Wang, T., Aoki, T., Bartlett, J.D., Nikai, H. J. Dent. Res. (2000) [Pubmed]
  6. Immunohistochemical investigation of epidermal growth factor receptor expression in ameloblastomas. Ueno, S., Miyagawa, T., Kaji, R., Mushimoto, K., Shirasu, R. J. Pathol. (1994) [Pubmed]
  7. Positive (99mTc) diphosphonate and 67 Ga-citrate scans in ameloblastoma: case report. Olson, W.H., McCombs, R.K. J. Nucl. Med. (1977) [Pubmed]
  8. Polymorphisms in PTCH1 affect the risk of ameloblastoma. Kawabata, T., Takahashi, K., Sugai, M., Murashima-Suginami, A., Ando, S., Shimizu, A., Kosugi, S., Sato, T., Nishida, M., Murakami, K., Iizuka, T. J. Dent. Res. (2005) [Pubmed]
  9. Chemotherapy of metastatic ameloblastoma. A case report and review of the literature. Lanham, R.J. Oncology (1987) [Pubmed]
  10. Local invasiveness of ameloblastoma. Role played by matrix metalloproteinases and proliferative activity. Pinheiro, J.J., Freitas, V.M., Moretti, A.I., Jorge, A.G., Jaeger, R.G. Histopathology (2004) [Pubmed]
  11. Expression of integrin subunits alpha2, alpha3, alpha5, alphav, beta1, beta3 and beta4 in different histological types of ameloblastoma compared with dental germ, dental lamina and adult lining epithelium. Modolo, F., Martins, M.T., Loducca, S.V., de Araújo, V.C. Oral diseases. (2004) [Pubmed]
  12. Pathology of the desmoplastic ameloblastoma. Kishino, M., Murakami, S., Fukuda, Y., Ishida, T. J. Oral Pathol. Med. (2001) [Pubmed]
  13. K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas. Kumamoto, H., Takahashi, N., Ooya, K. J. Oral Pathol. Med. (2004) [Pubmed]
  14. Detection of cell cycle-related factors in ameloblastomas. Kumamoto, H., Kimi, K., Ooya, K. J. Oral Pathol. Med. (2001) [Pubmed]
  15. Immunohistochemical analysis of apoptosis-related factors (Fas, Fas ligand, caspase-3 and single-stranded DNA) in ameloblastomas. Kumamoto, H., Kimi, K., Ooya, K. J. Oral Pathol. Med. (2001) [Pubmed]
  16. p53 gene status and expression of p53, MDM2, and p14 proteins in ameloblastomas. Kumamoto, H., Izutsu, T., Ohki, K., Takahashi, N., Ooya, K. J. Oral Pathol. Med. (2004) [Pubmed]
  17. Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) and heat shock proteins (HSPs) in ameloblastomas. Kumamoto, H., Suzuki, T., Ooya, K. J. Oral Pathol. Med. (2002) [Pubmed]
  18. Immunohistochemical detection of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in ameloblastomas. Kumamoto, H., Yamauchi, K., Yoshida, M., Ooya, K. J. Oral Pathol. Med. (2003) [Pubmed]
  19. Telomerase activity and telomerase reverse transciptase (TERT) expression in ameloblastomas. Kumamoto, H., Kinouchi, Y., Ooya, K. J. Oral Pathol. Med. (2001) [Pubmed]
  20. Immunohistochemical detection of beta-catenin and adenomatous polyposis coli in ameloblastomas. Kumamoto, H., Ooya, K. J. Oral Pathol. Med. (2005) [Pubmed]
  21. Cloning and characterization of the human ameloblastin gene. Toyosawa, S., Fujiwara, T., Ooshima, T., Shintani, S., Sato, A., Ogawa, Y., Sobue, S., Ijuhin, N. Gene (2000) [Pubmed]
  22. Association between vascular endothelial growth factor (VEGF) expression and tumor angiogenesis in ameloblastomas. Kumamoto, H., Ohki, K., Ooya, K. J. Oral Pathol. Med. (2002) [Pubmed]
  23. Expression of Sonic hedgehog (SHH) signaling molecules in ameloblastomas. Kumamoto, H., Ohki, K., Ooya, K. J. Oral Pathol. Med. (2004) [Pubmed]
  24. Expression of parathyroid hormone-related protein (PTHrP), osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin (OPG) in ameloblastomas. Kumamoto, H., Ooya, K. J. Oral Pathol. Med. (2004) [Pubmed]
  25. Use of calretinin in the differential diagnosis of unicystic ameloblastomas. Coleman, H., Altini, M., Ali, H., Doglioni, C., Favia, G., Maiorano, E. Histopathology (2001) [Pubmed]
  26. Tuftelin mRNA is expressed in a human ameloblastoma tumor. Deutsch, D., Fermon, E., Lustmann, J., Dafni, L., Mao, Z., Leytin, V., Palmon, A. Connect. Tissue Res. (1998) [Pubmed]
  27. TRAIL cleaves caspase-8, -9 and -3 of AM-1 cells: a possible pathway for TRAIL to induce apoptosis in ameloblastoma. Sandra, F., Hendarmin, L., Nakao, Y., Nakamura, N., Nakamura, S. Tumour Biol. (2005) [Pubmed]
  28. Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells. Nagatsuka, H., Han, P.P., Tsujigiwa, H., Siar, C.H., Gunduz, M., Sugahara, T., Sasaki, A., Nakajima, M., Naomoto, Y., Nagai, N. Oral Oncol. (2005) [Pubmed]
  29. Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma. Tsujigiwa, H., Nagatsuka, H., Han, P.P., Gunduz, M., Siar, C.H., Oida, S., Nagai, N. Oral Oncol. (2005) [Pubmed]
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