Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Digitalis

Lee, T.C., Choi, D.Y. et al., Oh, J.W. et al., Petersen, M. et al., Wendroth, S. et al., et al.

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High impact information on Digitalis

This hypothesis is based on his twice having painted his physician holding a foxglove plant; that this medicine was used in the latter part of the 19th century in the treatment of epilepsy; and that the toxic effects of digitalis may have, in part, dictated the artist's technique [1].
Characterization and localization of progesterone 5 alpha-reductase from cell cultures of foxglove (Digitalis lanata EHRH) [2].
Reconstitution of cytochrome P-450-dependent digitoxin 12 beta-hydroxylase from cell cultures of foxglove (Digitalis lanata EHRH.) [3].
Treatment of foxglove extract poisoning with digoxin-specific Fab fragments [4].
We have isolated four different phenylethanoid glycosides (purpureaside A, desrhamnosyl acteoside, calceolarioside B and plantainoside D) from the leaves of Digitalis purpurea (foxglove) [5].

Anatomical context of Digitalis

In the present study, we isolated chrysoeriol from the leaves of Digitalis purpurea (foxglove), and studied its effect on the induction of the inducible nitric oxide synthase (iNOS) gene, and the mechanism of this induction in Raw264.7 macrophages [6].

References

Van Gogh's vision. Digitalis intoxication? Lee, T.C. JAMA (1981) [Pubmed]
Characterization and localization of progesterone 5 alpha-reductase from cell cultures of foxglove (Digitalis lanata EHRH). Wendroth, S., Seitz, H.U. Biochem. J. (1990) [Pubmed]
Reconstitution of cytochrome P-450-dependent digitoxin 12 beta-hydroxylase from cell cultures of foxglove (Digitalis lanata EHRH.). Petersen, M., Seitz, H.U. Biochem. J. (1988) [Pubmed]
Treatment of foxglove extract poisoning with digoxin-specific Fab fragments. Rich, S.A., Libera, J.M., Locke, R.J. Annals of emergency medicine. (1993) [Pubmed]
Effects of phenylethanoid glycosides from Digitalis purpurea L. on the expression of inducible nitric oxide synthase. Oh, J.W., Lee, J.Y., Han, S.H., Moon, Y.H., Kim, Y.G., Woo, E.R., Kang, K.W. J. Pharm. Pharmacol. (2005) [Pubmed]
Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation. Choi, D.Y., Lee, J.Y., Kim, M.R., Woo, E.R., Kim, Y.G., Kang, K.W. J. Biomed. Sci. (2005) [Pubmed]

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