Disease relevance of Inguinal Canal

• After establishing a CO2 pneumoperitoneum, the contralateral side is checked for patency of the internal inguinal ring [1].
• Cryptorchidism in adult male rats was induced by pushing testes of either side into abdomen and suturing the inguinal canals [2].

High impact information on Inguinal Canal

• Of the 10 testes 8 became palpable after HCG treatment, including 1 atrophic nubbin located in the inguinal canal [3].
• The distal end of the vas was found at the internal inguinal ring or in the pelvic cavity in 57.1% of the vasa and more than 3 cm. of the vas had been resected in 37% [4].
• The world literature and embryological implications of Wilms tumor in the inguinal canal are reviewed [5].
• Half of the peritoneal sacs were pushed up and out of the inguinal canal; 18 months later there were no recurrences (inguinal or femoral) [6].
• Blocking androgen receptor action interferes with normal development of the inguinal canal, which suggests that it is this aspect of inguinoscrotal testicular descent that is androgen dependent [7].

Anatomical context of Inguinal Canal

• Samples of vas deferens from the region proximal to the testis and the region at the internal inguinal ring were incubated in vitro with tritium-labeled dihydrotestosterone ([3H]-DHT) [8].
• Testes of rats fell into the abdominal cavity when a tail harness was used, but ligation of the inguinal canal prevented this repositioning [9].
• The original description of the transversalis fascia and the internal inguinal ring by Astley Cooper in 1804 is recounted along with the immediate recognition of its importance by other surgical anatomists [10].
• Through a midline incision the hernial content was mobilized, reduced through the inguinal ring and removed from the abdomen with both ovaries, tubes and uterus [11].

Gene context of Inguinal Canal

• Descent of the testes through the inguinal canal is an interplay between abdominal pressure, a patent processus vaginalis, and androgen-induced gubernacular regression [12].
• RESULTS: In 98 boys (110 testes) the testes were impalpable or high within the inguinal canal and they were explored using the APP approach [13].

References